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Gene Review

Hsd17b1  -  hydroxysteroid (17-beta) dehydrogenase 1

Rattus norvegicus

Synonyms: 17-beta-HSD 1, 17-beta-hydroxysteroid dehydrogenase type 1, Edh17b1, Estradiol 17-beta-dehydrogenase 1
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Disease relevance of Hsd17b1


High impact information on Hsd17b1


Chemical compound and disease context of Hsd17b1


Biological context of Hsd17b1


Anatomical context of Hsd17b1


Associations of Hsd17b1 with chemical compounds


Regulatory relationships of Hsd17b1


Other interactions of Hsd17b1


Analytical, diagnostic and therapeutic context of Hsd17b1


  1. Stiff-man syndrome: identification of 17 beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen. Dinkel, K., Rickert, M., Möller, G., Adamski, J., Meinck, H.M., Richter, W. J. Neuroimmunol. (2002) [Pubmed]
  2. Inhibition of testicular testosterone biosynthesis following experimental varicocele in rats. Rajfer, J., Turner, T.T., Rivera, F., Howards, S.S., Sikka, S.C. Biol. Reprod. (1987) [Pubmed]
  3. Enhancement of estradiol potency by the 17 beta-hydroxysteroid dehydrogenase inhibitor, 16-methylene E2 in vivo. McDonald, Z.A., Slikker, W., Fu, P.P., Bailey, J.R., Lipe, G.W., Unruh, L.E. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  4. Effect of dihydrotestosterone on serum concentrations of alpha 2u-globulin and on spermatogenesis in melatonin-treated rats. Mandal, H., Ghosh, P.K., Biswas, N.M. J. Endocrinol. (1990) [Pubmed]
  5. Inhibition of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase by antiestrogens. Santner, S.J., Santen, R.J. J. Steroid Biochem. Mol. Biol. (1993) [Pubmed]
  6. Transformation of cultured rat ovarian surface epithelial cells by Kirsten murine sarcoma virus. Adams, A.T., Auersperg, N. Cancer Res. (1981) [Pubmed]
  7. Testosterone metabolism by the rat gastrointestinal tract, in vitro and in vivo. Farthing, M.J., Vinson, G.P., Edwards, C.R., Dawson, A.M. Gut (1982) [Pubmed]
  8. Rat 17 beta-hydroxysteroid dehydrogenase type IV is a novel peroxisome proliferator-inducible gene. Corton, J.C., Bocos, C., Moreno, E.S., Merritt, A., Marsman, D.S., Sausen, P.J., Cattley, R.C., Gustafsson, J.A. Mol. Pharmacol. (1996) [Pubmed]
  9. Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. Thompson, C.J., Ross, S.M., Gaido, K.W. Endocrinology (2004) [Pubmed]
  10. Gonadal toxicity of short term chronic endosulfan exposure to male rats. Singh, S.K., Pandey, R.S. Indian J. Exp. Biol. (1989) [Pubmed]
  11. Time-studies of the changes in the sex-dependent activities of enzymes of hepatic steroid metabolism in the rat during oestrogen administration. Lax, E.R., Kreuzfelder, E., Schriefers, H. Hoppe-Seyler's Z. Physiol. Chem. (1979) [Pubmed]
  12. Rat 17 beta-hydroxysteroid dehydrogenase type 1: primary structure and regulation of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo. Ghersevich, S., Nokelainen, P., Poutanen, M., Orava, M., Autio-Harmainen, H., Rajaniemi, H., Vihko, R. Endocrinology (1994) [Pubmed]
  13. Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes. Akinola, L.A., Poutanen, M., Vihko, R. Endocrinology (1996) [Pubmed]
  14. A direct effect of medroxyprogesterone acetate on 17 beta-hydroxysteroid dehydrogenase in adult rat testis. Satyaswaroop, P.G., Gurpide, E. Endocrinology (1978) [Pubmed]
  15. Testosterone metabolism by proximal and distal regions of the vas deferens from immature and mature rats. Seethalakshmi, L., Rodriguez-Rigau, L.J., Steinberger, A. Biol. Reprod. (1982) [Pubmed]
  16. Identification of the cytochrome P-450 isozymes responsible for testosterone oxidation in rat lung, kidney, and testis: evidence that cytochrome P-450a (P450IIA1) is the physiologically important testosterone 7 alpha-hydroxylase in rat testis. Sonderfan, A.J., Arlotto, M.P., Parkinson, A. Endocrinology (1989) [Pubmed]
  17. Measurement of estradiol-17 beta dehydrogenase activity in rat endometrium during the estrous cycle and the first half of pregnancy. Kreitmann, O., Amr, S., Bayard, F., Faye, J.C. Biol. Reprod. (1980) [Pubmed]
  18. Further studies on in vitro steroidogenesis by luteal cells from long-term hypophysectomized rats. Kim, I., Greenwald, G.S. Biol. Reprod. (1984) [Pubmed]
  19. Effect of estrone on the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in the rat: a model of postmenopausal breast cancer. Li, S., Martel, C., Dauvois, S., Bélanger, A., Labrie, F. Endocrinology (1994) [Pubmed]
  20. Hormonal effects of ketoconazole in vivo in the male rat: mechanism of action. Bhasin, S., Sikka, S., Fielder, T., Sod-Moriah, U., Levine, H.B., Swerdloff, R.S., Rajfer, J. Endocrinology (1986) [Pubmed]
  21. The hypothalamic-pituitary-gonadal axis during hyperthyroidism in the rat. Schneider, G., Kopach, K., Ohanian, H., Bonnefond, V., Mittler, J.C., Ertel, N.H. Endocrinology (1979) [Pubmed]
  22. Arachidonic acid metabolites as intratesticular factors controlling androgen production. Reddy, G.P., Prasad, M., Sailesh, S., Kumar, Y.V., Reddanna, P. Int. J. Androl. (1993) [Pubmed]
  23. Aromatase-inhibitors of the androstenedione-type activate the 17 beta-hydroxysteroid-dehydrogenase in the rat testis tissue suspension model. Schröder, H., Ziegler, M., el Etreby, M.F. J. Steroid Biochem. (1988) [Pubmed]
  24. Relationship between induction of mammary tumors and change of testicular functions in male rats following gamma-ray irradiation and/or diethylstilbestrol. Inano, H., Suzuki, K., Onoda, M., Wakabayashi, K. Carcinogenesis (1996) [Pubmed]
  25. Hormonal regulation of rat 17 beta-hydroxysteroid dehydrogenase type 1 in cultured rat granulosa cells: effects of recombinant follicle-stimulating hormone, estrogens, androgens, and epidermal growth factor. Ghersevich, S., Poutanen, M., Tapanainen, J., Vihko, R. Endocrinology (1994) [Pubmed]
  26. Effect of alpha 2u-globulin on serum concentration of gonadotrophins and testicular activity in oestrogen-treated rats. Biswas, N.M., Ghosh, P.K., Ghosh, K.K., Neuhaus, O.W. J. Endocrinol. (1983) [Pubmed]
  27. Role of 17 beta-hydroxysteroid dehydrogenase in the modulation of nuclear estradiol receptor binding by progesterone in the rat anterior pituitary gland and the uterus. Fuentes, M.A., Muldoon, T.G., Mahesh, V.B. J. Steroid Biochem. Mol. Biol. (1990) [Pubmed]
  28. Mechanism of action of alpha-melanocyte-stimulating hormone in rat preputial glands: the role of androgen metabolism. Hay, J.B., Meddis, D., Thody, A.J., Shuster, S. J. Endocrinol. (1982) [Pubmed]
  29. Expression of 17 beta-hydroxysteroid dehydrogenase in the rat ovary during follicular development and luteinization induced with pregnant mare serum gonadotrophin and human chorionic gonadotrophin. Ghersevich, S.A., Poutanen, M.H., Rajaniemi, H.J., Vihko, R.K. J. Endocrinol. (1994) [Pubmed]
  30. Effect of lithium chloride on testicular steroidogenesis and gametogenesis in immature male rats. Ghosh, P.K., Biswas, N.M., Ghosh, D. Acta Endocrinol. (1991) [Pubmed]
  31. Time-studies of the changes in the sex-dependent activities of enzymes of hepatic steroid metabolism in the rat following gonadectomy. Lax, E.R., Kreuzfelder, E., Schriefers, H. Hoppe-Seyler's Z. Physiol. Chem. (1979) [Pubmed]
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