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Gene Review

PROX1  -  prospero homeobox 1

Gallus gallus

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High impact information on PROX1


Biological context of PROX1

  • Chicken Prox 1 cDNAs were isolated from 14 day embryonic chicken lenses, and a complete open reading frame encoding an 83 kDa protein was elucidated [5].

Anatomical context of PROX1

  • At later stages of development, Prox 1 mRNA was observed throughout the lens, but it appeared more abundant around the bow region of the equator than in the anterior epithelium or the fibers [5].

Other interactions of PROX1


  1. Mafs, Prox1, and Pax6 can regulate chicken betaB1-crystallin gene expression. Cui, W., Tomarev, S.I., Piatigorsky, J., Chepelinsky, A.B., Duncan, M.K. J. Biol. Chem. (2004) [Pubmed]
  2. Effects of follistatin overexpression on cell differentiation in the chick embryo retina. Moreira, E.F., Adler, R. Dev. Biol. (2006) [Pubmed]
  3. Heterogeneity of horizontal cells in the chicken retina. Fischer, A.J., Stanke, J.J., Aloisio, G., Hoy, H., Stell, W.K. J. Comp. Neurol. (2007) [Pubmed]
  4. Endogenous origin of the lymphatics in the avian chorioallantoic membrane. Papoutsi, M., Tomarev, S.I., Eichmann, A., Pröls, F., Christ, B., Wilting, J. Dev. Dyn. (2001) [Pubmed]
  5. Chicken homeobox gene Prox 1 related to Drosophila prospero is expressed in the developing lens and retina. Tomarev, S.I., Sundin, O., Banerjee-Basu, S., Duncan, M.K., Yang, J.M., Piatigorsky, J. Dev. Dyn. (1996) [Pubmed]
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