Gene Review:
PROX1 - prospero homeobox 1
Homo sapiens
Synonyms:
Homeobox prospero-like protein PROX1, PROX-1, Prospero homeobox protein 1
Garrafa,
Trainini,
Benetti,
Saba,
Fezzardi,
Lorusso,
Borghetti,
Bottio,
Ceri,
Portolani,
Bonardlli,
Giulini,
Annibale,
Corradi,
Imberti,
Caruso,
Dadras,
North,
Bertoncini,
Mihm,
Detmar,
Nagai,
Li,
Hatano,
Toshihito,
Yuge,
Ito,
Utsumi,
Saito,
Kinoshita,
Wilting,
Papoutsi,
Christ,
Nicolaides,
von Kaisenberg,
Borges,
Stark,
Alitalo,
Tomarev,
Niemeyer,
Rössler,
Parent,
Elliott,
Pleasure,
Barbaro,
Lowenstein,
Geissler,
Dashkevich,
Fischer,
Fries,
Kuhn-Régnier,
Addicks,
Mehlhorn,
Bloch,
- Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. Nagai, H., Li, Y., Hatano, S., Toshihito, O., Yuge, M., Ito, E., Utsumi, M., Saito, H., Kinoshita, T. Genes Chromosomes Cancer (2003)
- Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Hong, Y.K., Foreman, K., Shin, J.W., Hirakawa, S., Curry, C.L., Sage, D.R., Libermann, T., Dezube, B.J., Fingeroth, J.D., Detmar, M. Nat. Genet. (2004)
- Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system. Laerm, A., Helmbold, P., Goldberg, M., Dammann, R., Holzhausen, H.J., Ballhausen, W.G. J. Hepatol. (2007)
- LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Mouta Carreira, C., Nasser, S.M., di Tomaso, E., Padera, T.P., Boucher, Y., Tomarev, S.I., Jain, R.K. Cancer Res. (2001)
- Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Dadras, S.S., North, P.E., Bertoncini, J., Mihm, M.C., Detmar, M. Mod. Pathol. (2004)
- Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Dyer, M.A., Livesey, F.J., Cepko, C.L., Oliver, G. Nat. Genet. (2003)
- Prox1 function is crucial for mouse lens-fibre elongation. Wigle, J.T., Chowdhury, K., Gruss, P., Oliver, G. Nat. Genet. (1999)
- Molecular lymphangiogenesis: new players. Tammela, T., Petrova, T.V., Alitalo, K. Trends Cell Biol. (2005)
- Targeting of Sp1 to a non-Sp1 site in the human neurofilament (H) promoter via an intermediary DNA-binding protein. Elder, G.A., Liang, Z., Li, C., Lazzarini, R.A. Nucleic Acids Res. (1992)
- Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue. Steffensen, K.R., Holter, E., Båvner, A., Nilsson, M., Pelto-Huikko, M., Tomarev, S., Treuter, E. EMBO Rep. (2004)
- A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. Song, K.H., Li, T., Chiang, J.Y. J. Biol. Chem. (2006)
- Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors. Reis, R.M., Reis-Filho, J.S., Longatto Filho, A., Tomarev, S., Silva, P., Lopes, J.M. Pathol. Res. Pract. (2005)
- Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts. Rodriguez-Niedenführ, M., Papoutsi, M., Christ, B., Nicolaides, K.H., von Kaisenberg, C.S., Tomarev, S.I., Wilting, J. Anat. Embryol. (2001)
- Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation. Nelson, B.H., McIntosh, B.C., Rosencrans, L.L., Greenberg, P.D. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy. Parent, J.M., Elliott, R.C., Pleasure, S.J., Barbaro, N.M., Lowenstein, D.H. Ann. Neurol. (2006)
- Effects of reduction temperature and metal-support interactions on the catalytic activity of Pt/gamma-Al2O3 and Pt/TiO2 for the oxidation of CO in the presence and absence of H2. Alexeev, O.S., Chin, S.Y., Engelhard, M.H., Ortiz-Soto, L., Amiridis, M.D. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005)
- Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene. Qin, J., Gao, D.M., Jiang, Q.F., Zhou, Q., Kong, Y.Y., Wang, Y., Xie, Y.H. Mol. Endocrinol. (2004)
- IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells. Gröger, M., Loewe, R., Holnthoner, W., Embacher, R., Pillinger, M., Herron, G.S., Wolff, K., Petzelbauer, P. J. Immunol. (2004)
- Prox1 expression patterns in the developing and adult murine brain. Lavado, A., Oliver, G. Dev. Dyn. (2007)
- Isolation, purification, and heterogeneity of human lymphatic endothelial cells from different tissues. Garrafa, E., Trainini, L., Benetti, A., Saba, E., Fezzardi, L., Lorusso, B., Borghetti, P., Bottio, T., Ceri, E., Portolani, N., Bonardlli, S., Giulini, S.M., Annibale, G., Corradi, A., Imberti, L., Caruso, A. Lymphology. (2005)
- Determination of Microvessel Density by Quantitative Real-time PCR in Esophageal Cancer: Correlation with Histologic Methods, Angiogenic Growth Factor Expression, and Lymph Node Metastasis. Loges, S., Clausen, H., Reichelt, U., Bubenheim, M., Erbersdobler, A., Schurr, P., Yekebas, E., Schuch, G., Izbicki, J., Pantel, K., Bokemeyer, C., Fiedler, W. Clin. Cancer Res. (2007)
- First year changes of myocardial lymphatic endothelial markers in heart transplant recipients. Geissler, H.J., Dashkevich, A., Fischer, U.M., Fries, J.W., Kuhn-Régnier, F., Addicks, K., Mehlhorn, U., Bloch, W. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2006)
- The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues. Wilting, J., Papoutsi, M., Christ, B., Nicolaides, K.H., von Kaisenberg, C.S., Borges, J., Stark, G.B., Alitalo, K., Tomarev, S.I., Niemeyer, C., Rössler, J. FASEB J. (2002)
- Prox1 is differentially localized during lens development. Duncan, M.K., Cui, W., Oh, D.J., Tomarev, S.I. Mech. Dev. (2002)
- Regulation of Prox 1 during lens regeneration. Del Rio-Tsonis, K., Tomarev, S.I., Tsonis, P.A. Invest. Ophthalmol. Vis. Sci. (1999)