The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ASL1  -  argininosuccinate lyase

Gallus gallus

Synonyms: ASL, CRYD1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on LOC396498


Biological context of LOC396498


Anatomical context of LOC396498


Associations of LOC396498 with chemical compounds

  • Published evidence indicates that the chick delta 1 crystallin gene encodes the major structural protein of embryonic lens fibres, whereas the closely related delta 2 gene may encode the urea-cycle enzyme argininosuccinate lyase (ASL) [12].
  • These data confirm the roles of histidine in the catalytic process of this enzyme-crystallin and suggest that the change of His91 to Gln91 observed in the duck and chicken delta 1-crystallin molecules may be sufficient to account for the lack of enzymatic activity of those proteins [13].
  • His91, His110, His162 and His178, were converted to asparagine residues in an effort to define the role of histidines in the catalytic process of this enzyme-crystallin and to explain the lack of enzyme activity in the delta 1-crystallin protein [13].

Other interactions of LOC396498

  • This accumulation of delta-crystallin RNA during lens induction operates selectively on the delta 1-crystallin transcripts whereas delta 2-crystallin/argininsosuccinate lyase RNA is detectable at lower levels in all developing ocular tissues throughout this period [14].
  • A nuclear factor delta EF1, which binds to the essential element of the delta 1-crystallin enhancer core, was molecularly cloned from the chicken by a southwestern method [15].
  • A 77-nucleotide DNA segment of the delta 1-crystallin promoter from nucleotide positions-120 to -43 confers sensitivity to insulin and IGF-I [4].

Analytical, diagnostic and therapeutic context of LOC396498


  1. Lens-specific enhancer in the third intron regulates expression of the chicken delta 1-crystallin gene. Hayashi, S., Goto, K., Okada, T.S., Kondoh, H. Genes Dev. (1987) [Pubmed]
  2. Involvement of SOX proteins in lens-specific activation of crystallin genes. Kamachi, Y., Sockanathan, S., Liu, Q., Breitman, M., Lovell-Badge, R., Kondoh, H. EMBO J. (1995) [Pubmed]
  3. Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene. Cvekl, A., Sax, C.M., Li, X., McDermott, J.B., Piatigorsky, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Transcriptional stimulation of the delta 1-crystallin gene by insulin-like growth factor I and insulin requires DNA cis elements in chicken. Alemany, J., Borras, T., de Pablo, F. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  5. The complete sequence of the chicken delta 1 crystallin gene and its 5' flanking region. Nickerson, J.M., Wawrousek, E.F., Hawkins, J.W., Wakil, A.S., Wistow, G.J., Thomas, G., Norman, B.L., Piatigorsky, J. J. Biol. Chem. (1985) [Pubmed]
  6. Gene sharing by delta-crystallin and argininosuccinate lyase. Piatigorsky, J., O'Brien, W.E., Norman, B.L., Kalumuck, K., Wistow, G.J., Borras, T., Nickerson, J.M., Wawrousek, E.F. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  7. Lens-preferred activity of chicken delta 1- and delta 2-crystallin enhancers in transgenic mice and evidence for retinoic acid-responsive regulation of the delta 1-crystallin gene. Li, X., Cvekl, A., Bassnett, S., Piatigorsky, J. Dev. Genet. (1997) [Pubmed]
  8. Developmental regulation of hypomethylation of delta-crystallin genes in chicken embryo lens cells. Sullivan, C.H., Norman, J.T., Borrás, T., Grainger, R.M. Mol. Cell. Biol. (1989) [Pubmed]
  9. Independent regulation of two coexpressed delta-crystallin genes in chick lens and nonlens tissues. Head, M.W., Triplett, E.L., Clayton, R.M. Exp. Cell Res. (1991) [Pubmed]
  10. The chicken delta 1-crystallin gene promoter: binding of transcription factor(s) to the upstream G+C-rich region is necessary for promoter function in vitro. Das, G.C., Piatigorsky, J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  11. Lens-specific activity of the chicken delta 1-crystallin enhancer in the mouse. Takahashi, Y., Hanaoka, K., Goto, K., Kondoh, H. Int. J. Dev. Biol. (1994) [Pubmed]
  12. Expression in non-lens tissues of an enzyme activity related to the 'lens-specific' protein, delta crystallin. de Pomerai, D.I., Ip, W.K., McLaughlin, M., Perry, K.C. Development (1991) [Pubmed]
  13. Exploring the role of histidines in the catalytic activity of duck delta-crystallins using site-directed mutagenesis. Patejunas, G., Barbosa, P., Lacombe, M., O'Brien, W.E. Exp. Eye Res. (1995) [Pubmed]
  14. Localization of delta-crystallin RNA during lens morphogenesis and differentiation in the normal and talpid3 chick embryo. Head, M.W., Triplett, E.L., Ede, D.A., Clayton, R.M. Int. J. Dev. Biol. (1992) [Pubmed]
  15. Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis. Funahashi, J., Sekido, R., Murai, K., Kamachi, Y., Kondoh, H. Development (1993) [Pubmed]
  16. Developmental regulation of the chicken delta 1-crystallin gene: analysis by transgenesis and gene dissection. Kondoh, H., Katoh, K., Takahashi, Y., Goto, K., Hayashi, S., Okada, T.S. Cell Differ. Dev. (1988) [Pubmed]
WikiGenes - Universities