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Gene Review

ASL1  -  argininosuccinate lyase

Gallus gallus

Synonyms: ASL, CRYD1
 
 
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High impact information on LOC396498

 

Biological context of LOC396498

 

Anatomical context of LOC396498

 

Associations of LOC396498 with chemical compounds

  • Published evidence indicates that the chick delta 1 crystallin gene encodes the major structural protein of embryonic lens fibres, whereas the closely related delta 2 gene may encode the urea-cycle enzyme argininosuccinate lyase (ASL) [12].
  • These data confirm the roles of histidine in the catalytic process of this enzyme-crystallin and suggest that the change of His91 to Gln91 observed in the duck and chicken delta 1-crystallin molecules may be sufficient to account for the lack of enzymatic activity of those proteins [13].
  • His91, His110, His162 and His178, were converted to asparagine residues in an effort to define the role of histidines in the catalytic process of this enzyme-crystallin and to explain the lack of enzyme activity in the delta 1-crystallin protein [13].
 

Other interactions of LOC396498

  • This accumulation of delta-crystallin RNA during lens induction operates selectively on the delta 1-crystallin transcripts whereas delta 2-crystallin/argininsosuccinate lyase RNA is detectable at lower levels in all developing ocular tissues throughout this period [14].
  • A nuclear factor delta EF1, which binds to the essential element of the delta 1-crystallin enhancer core, was molecularly cloned from the chicken by a southwestern method [15].
  • A 77-nucleotide DNA segment of the delta 1-crystallin promoter from nucleotide positions-120 to -43 confers sensitivity to insulin and IGF-I [4].
 

Analytical, diagnostic and therapeutic context of LOC396498

References

  1. Lens-specific enhancer in the third intron regulates expression of the chicken delta 1-crystallin gene. Hayashi, S., Goto, K., Okada, T.S., Kondoh, H. Genes Dev. (1987) [Pubmed]
  2. Involvement of SOX proteins in lens-specific activation of crystallin genes. Kamachi, Y., Sockanathan, S., Liu, Q., Breitman, M., Lovell-Badge, R., Kondoh, H. EMBO J. (1995) [Pubmed]
  3. Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene. Cvekl, A., Sax, C.M., Li, X., McDermott, J.B., Piatigorsky, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Transcriptional stimulation of the delta 1-crystallin gene by insulin-like growth factor I and insulin requires DNA cis elements in chicken. Alemany, J., Borras, T., de Pablo, F. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  5. The complete sequence of the chicken delta 1 crystallin gene and its 5' flanking region. Nickerson, J.M., Wawrousek, E.F., Hawkins, J.W., Wakil, A.S., Wistow, G.J., Thomas, G., Norman, B.L., Piatigorsky, J. J. Biol. Chem. (1985) [Pubmed]
  6. Gene sharing by delta-crystallin and argininosuccinate lyase. Piatigorsky, J., O'Brien, W.E., Norman, B.L., Kalumuck, K., Wistow, G.J., Borras, T., Nickerson, J.M., Wawrousek, E.F. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  7. Lens-preferred activity of chicken delta 1- and delta 2-crystallin enhancers in transgenic mice and evidence for retinoic acid-responsive regulation of the delta 1-crystallin gene. Li, X., Cvekl, A., Bassnett, S., Piatigorsky, J. Dev. Genet. (1997) [Pubmed]
  8. Developmental regulation of hypomethylation of delta-crystallin genes in chicken embryo lens cells. Sullivan, C.H., Norman, J.T., Borrás, T., Grainger, R.M. Mol. Cell. Biol. (1989) [Pubmed]
  9. Independent regulation of two coexpressed delta-crystallin genes in chick lens and nonlens tissues. Head, M.W., Triplett, E.L., Clayton, R.M. Exp. Cell Res. (1991) [Pubmed]
  10. The chicken delta 1-crystallin gene promoter: binding of transcription factor(s) to the upstream G+C-rich region is necessary for promoter function in vitro. Das, G.C., Piatigorsky, J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  11. Lens-specific activity of the chicken delta 1-crystallin enhancer in the mouse. Takahashi, Y., Hanaoka, K., Goto, K., Kondoh, H. Int. J. Dev. Biol. (1994) [Pubmed]
  12. Expression in non-lens tissues of an enzyme activity related to the 'lens-specific' protein, delta crystallin. de Pomerai, D.I., Ip, W.K., McLaughlin, M., Perry, K.C. Development (1991) [Pubmed]
  13. Exploring the role of histidines in the catalytic activity of duck delta-crystallins using site-directed mutagenesis. Patejunas, G., Barbosa, P., Lacombe, M., O'Brien, W.E. Exp. Eye Res. (1995) [Pubmed]
  14. Localization of delta-crystallin RNA during lens morphogenesis and differentiation in the normal and talpid3 chick embryo. Head, M.W., Triplett, E.L., Ede, D.A., Clayton, R.M. Int. J. Dev. Biol. (1992) [Pubmed]
  15. Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis. Funahashi, J., Sekido, R., Murai, K., Kamachi, Y., Kondoh, H. Development (1993) [Pubmed]
  16. Developmental regulation of the chicken delta 1-crystallin gene: analysis by transgenesis and gene dissection. Kondoh, H., Katoh, K., Takahashi, Y., Goto, K., Hayashi, S., Okada, T.S. Cell Differ. Dev. (1988) [Pubmed]
 
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