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Gene Review

RET  -  ret proto-oncogene

Gallus gallus

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High impact information on RET

  • These observations suggest that possible combinations of novel unidentified receptors acting with RET or with GFRalphas may mediate GDNF-derived signals and indicate that GDNF or other family members may have previously unidentified actions in early organogenesis in the chick embryo [1].
  • Quantities of the Group 1 proteins in RET/PE/CH of each of the three types of animals were found to be related to genotype; the amounts of each did not change with development [2].
  • Using the technique of two-dimensional gel electrophoresis, we have identified two groups of proteins whose expression in the retina/pigment epithelium/choroid (RET/PE/CH) of +/+, +/rd and rd/rd chicks is related to genotype [2].
  • Four different ligand-receptor binding pairs of the GDNF (glial cell line-derived neurotrophic factor) family exist in mammals, and they all signal via the transmembrane RET receptor tyrosine kinase [3].

Biological context of RET


  1. Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Homma, S., Oppenheim, R.W., Yaginuma, H., Kimura, S. Dev. Biol. (2000) [Pubmed]
  2. Analysis of proteins in developing rd (retinal degeneration) chick retina using two-dimensional gel electrophoresis. Semple-Rowland, S.L., Ulshafer, R.J. Exp. Eye Res. (1989) [Pubmed]
  3. Evolution of the GDNF family ligands and receptors. Airaksinen, M.S., Holm, L., Hätinen, T. Brain Behav. Evol. (2006) [Pubmed]
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