High impact information on TTR

• The embryo synthesizes every plasma protein including fetoproteins and "adult" proteins (prealbumin, albumin, and transferrin) [1].
• In concordance with the intraoocytic localization in an endosomal compartment, ligand blotting and chemical cross-linking experiments revealed the presence of a approximately 115-kDa TTR-binding oocyte membrane protein [2].
• Furthermore, in contrast to the serum levels of the yolk precursor lipoproteins, those of TTR were not significantly changed by estrogen; thus, TTR represents a newly defined, estrogen-independent class of yolk precursor proteins [2].
• These data strongly suggest that oocytic TTR is derived from the circulation, where it is a constitutive component, and deposited into yolk as a result of endocytosis mediated by a specific receptor [2].
• T3 is subsequently bound to its carrier protein, transthyretin (TTR), to allow transport through the cerebrospinal fluid [3].

Biological context of TTR

• A structure-activity relationship between the phenol compounds and TTR (TTR assay) and TR (TR assay) was established [4].
• Genetic polymorphism of a protein, tentatively designated as Pr M prealbumin, was observed [5].

Anatomical context of TTR

• New genetic polymorphism recognized in the prealbumin region of chicken egg yolk [5].
• Moreover, the component also showed a lack of binding affinity for prealbumin (PA), excluding the possibility that chicken plasma RBP was contaminated in the cytosol [6].

Associations of TTR with chemical compounds

• For transport in serum, retinol is bound to retinol-binding protein (RBP), which in turn forms a complex with transthyretin (TTR) [7].
• The presence of serum transferrin, two embryo-specific alpha-globulins, and a prealbumin were demonstrated by acrylamide gel analysis [8].

Analytical, diagnostic and therapeutic context of TTR

• Western blots of yolk collected from oocytes at different stages of growth show that both RBP and TTR, but not albumin, are more abundant at early stages relative to total yolk protein [7].

References