Disease relevance of TTR

• The maximum TTR during prolonged hyperthermia at 41 degrees C was 2.4 by approximately 50 min [1].
• The finding of TTR synthesis in the eye may explain ocular involvement in the familial amyloidotic polyneuropathies [2].
• A prealbumin (electrophoretic mobility relative to albumin; Ra 1.28) and a pretransferrin (Ra .72) were found in uterine flushings [3].

High impact information on TTR

• We postulate that ocular RBP and TTR are involved in the intraocular translocation of retinol [4].
• Preliminary immunohistochemical data indicate that the retinal pigment epithelium is a major site of TTR immunoreactivity in the rat [2].
• Transthyretin (TTR, prealbumin) is a 55 kDa protein which plays an important role in the plasma transport of thyroxine and retinol [2].
• Although the liver and choroid plexus are the two major known sites of TTR synthesis, several lines of evidence suggest the possibility of a separate ocular source of TTR [2].
• In comparison to the precalving values the concentrations of albumin, prealbumin and transferrin were all lower after parturition [5].

Anatomical context of TTR

• Blood serum concentrations of protein, albumin, prealbumin, transferrin, amino acids and urea were measured in 31 healthy cows 0 to 6 weeks before and 3 to 8 weeks after parturition [5].

Analytical, diagnostic and therapeutic context of TTR

• The bovine prealbumin had alpha1-mobility on agarose gel electrophoresis at pH 8 [6].

References