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LBR  -  lamin B receptor

Gallus gallus

 
 
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High impact information on RCJMB04_11a8

 

Biological context of RCJMB04_11a8

 

Associations of RCJMB04_11a8 with chemical compounds

  • Mitotic phosphorylation of the lamin B receptor by a serine/arginine kinase and p34(cdc2) [4].
  • To identify a threonine residue specifically phosphorylated in mitosis and the responsible protein kinase, wild-type and mutant LBR nucleoplasmic domain fusion proteins were phosphorylated in vitro by p34cdc2-type protein kinase [5].
  • This enzyme (RS kinase) specifically phosphorylates arginine-serine dipeptide motifs located at the NH2-terminal domain of LBR and regulates its interactions with other nuclear envelope proteins [4].
 

Physical interactions of RCJMB04_11a8

 

Analytical, diagnostic and therapeutic context of RCJMB04_11a8

  • To identify determinants that sort LBR from its site of integration (RER and outer nuclear membrane) to the inner nuclear membrane, we prepared full-length, truncated, and chimeric cDNA constructs of chick LBR, transfected these into mammalian cells and detected the expressed protein by immunofluorescence microscopy using appropriate antibodies [2].

References

 
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