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Gene Review

HPGDS  -  hematopoietic prostaglandin D synthase

Gallus gallus

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Disease relevance of PGDS


High impact information on PGDS


Anatomical context of PGDS


Associations of PGDS with chemical compounds

  • In conclusion, ADL, CYP450, ovoinhibitor, and PGDS represent the novel targets of estrogen, which regulates the transcriptional activity of these genes [6].
  • Four cDNA fragments that displayed dramatic change after estrogen administration were identified as liver adenylosuccinate lyase (ADL), phenobarbital-inducible cytochrome P-450 (CYP450), ovoinhibitor, and glutathione-dependent prostaglandin D2 synthase (PGDS) [6].

Analytical, diagnostic and therapeutic context of PGDS

  • Western blotting experiments showed that among the organs studied, the expression of PGDS in the female chicken is highest in liver, kidney and intestine, with only small amounts of the enzyme being found in chicken spleen; in contrast, the rat has highest levels of PGDS in the spleen [1].


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