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Gene Review

IL13  -  interleukin 13

Sus scrofa

Synonyms: IL-13, L13
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High impact information on IL-13

  • T-cells exposed to HEWL-treated mDCs expressed high IL-13 and moderate IL-10 and IFN-gamma, suggesting T-helper 2 (Th-2) bias [1].
  • Addition of any cytokine during HEWL treatment of mDCs reduced subsequent expression of IL-10 and IL-13 by T-cells [1].
  • Interestingly, however, whilst IFN-gamma-supplemented cultures largely consisted of immunoglobulin M (IgM)-positive cells, cultures with IL-13 or IL-4 contained a significantly increased proportion of IgG-positive cells [2].
  • This analysis shows that the generation of MoDCs in IL-13 yields cells of equivalent phenotype and function as IL-4 generated DC [3].
  • Critically, porcine IL-13/GM-CSF MoDC have the unique ability to stimulate a primary mixed lymphocyte response in vitro [3].

Anatomical context of IL-13


Other interactions of IL-13


Analytical, diagnostic and therapeutic context of IL-13

  • Messenger RNA was isolated from the T-cells and used to evaluate the effects of treatment on IL-12p35, IFN-gamma, IL-4, IL-10 and IL-13 expression using RT-PCR [1].


  1. Th-1/Th-2 type cytokine profiles of pig T-cells cultured with antigen-treated monocyte-derived dendritic cells. Raymond, C.R., Wilkie, B.N. Vaccine (2004) [Pubmed]
  2. Establishment of long-term CD154-dependent porcine B-cell cultures. Takamatsu, H., Andersen, J.K., Denyer, M.S., Parkhouse, R.M. Immunology (1999) [Pubmed]
  3. IL-13 replaces IL-4 in development of monocyte derived dendritic cells (MoDC) of swine. Bautista, E.M., Nfon, C., Ferman, G.S., Golde, W.T. Vet. Immunol. Immunopathol. (2007) [Pubmed]
  4. Molecular cloning of the swine IL-4 receptor alpha and IL-13 receptor 1-chains: effects of experimental Toxoplasma gondii, Ascaris suum and Trichuris suis infections on tissue mRNA levels. Zarlenga, D.S., Dawson, H., Kringel, H., Solano-Aguilar, G., Urban, J.F. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  5. Effects of antigen and recombinant porcine cytokines on pig dendritic cell cytokine expression in vitro. Raymond, C.R., Sidahmed, A.M., Wilkie, B.N. Vet. Immunol. Immunopathol. (2006) [Pubmed]
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