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Gene Review

mtlD  -  mannitol-1-phosphate 5-dehydrogenase

Escherichia coli UTI89

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Disease relevance of mtlD


High impact information on mtlD


Chemical compound and disease context of mtlD


Biological context of mtlD


  1. Overexpression of mtlD gene in transgenic Populus tomentosa improves salt tolerance through accumulation of mannitol. Hu, L., Lu, H., Liu, Q., Chen, X., Jiang, X. Tree Physiol. (2005) [Pubmed]
  2. Expression of a bacterial mtlD gene in transgenic tobacco leads to production and accumulation of mannitol. Tarczynski, M.C., Jensen, R.G., Bohnert, H.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Expression of bacterial mtlD in Saccharomyces cerevisiae results in mannitol synthesis and protects a glycerol-defective mutant from high-salt and oxidative stress. Chaturvedi, V., Bartiss, A., Wong, B. J. Bacteriol. (1997) [Pubmed]
  4. Mutations affecting transport of the hexitols D-mannitol, D-glucitol, and galactitol in Escherichia coli K-12: isolation and mapping. Lengeler, J. J. Bacteriol. (1975) [Pubmed]
  5. Molecular analysis of the mannitol operon of Clostridium acetobutylicum encoding a phosphotransferase system and a putative PTS-modulated regulator. Behrens, S., Mitchell, W., Bahl, H. Microbiology (Reading, Engl.) (2001) [Pubmed]
  6. Engineering of the metabolism of Saccharomyces cerevisiae for anaerobic production of mannitol. Costenoble, R., Adler, L., Niklasson, C., Lidén, G. FEMS Yeast Res. (2003) [Pubmed]
  7. Cloning, nucleotide sequence and expression of a mannitol dehydrogenase gene from Pseudomonas fluorescens DSM 50106 in Escherichia coli. Brünker, P., Altenbuchner, J., Kulbe, K.D., Mattes, R. Biochim. Biophys. Acta (1997) [Pubmed]
  8. Mannitol-specific enzyme II of the phosphoenolpyruvate-dependent phosphotransferase system of Staphylococcus carnosus. Sequence and expression in Escherichia coli and structural comparison with the enzyme IImannitol of Escherichia coli. Fischer, R., Hengstenberg, W. Eur. J. Biochem. (1992) [Pubmed]
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