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Chemical Compound Review

mannitol-1-P     [(2R,3R,4R,5R)-2,3,4,5,6...

Synonyms: CHEBI:16298, HMDB01530, AC1L2XCX, AR-1J3864, AC1Q6RV4, ...
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Disease relevance of mannitol-1-phosphate


High impact information on mannitol-1-phosphate


Chemical compound and disease context of mannitol-1-phosphate


Biological context of mannitol-1-phosphate


Anatomical context of mannitol-1-phosphate

  • In the presence of enzyme I and HPr of the PTS, and of membranes containing EIIMtl, the phospho group from [(R)-16O,17O,18O]PEP was transferred to D-mannitol to form mannitol 1-phosphate with overall inversion of the configuration at phosphorus with respect to that of PEP [16].
  • Transgenic tobacco (Nicotiana tabacum L, cv. SR-1) expressing mannitol 1-phosphate dehydrogenase, MTLD, in chloroplasts and myo-inositol O-methyltransferase, IMT1, in the cytosol after crossing of lines which expressed these foreign genes separately has been analysed [17].

Associations of mannitol-1-phosphate with other chemical compounds


Gene context of mannitol-1-phosphate


Analytical, diagnostic and therapeutic context of mannitol-1-phosphate

  • Comparison of secondary structure assignment to sequence alignments suggest the shortest members of this family, mannitol-1-phosphate 5-dehydrogenases, retain core elements but lack secondary structural components found on the surface of pfMDH [24].


  1. Plasmid-directed synthesis of enzymes required for D-mannitol transport and utilization in Escherichia coli. Lee, C.A., Jacobson, G.R., Saier, M.H. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  2. Metabolic engineering of mannitol production in Lactococcus lactis: influence of overexpression of mannitol 1-phosphate dehydrogenase in different genetic backgrounds. Wisselink, H.W., Mars, A.E., van der Meer, P., Eggink, G., Hugenholtz, J. Appl. Environ. Microbiol. (2004) [Pubmed]
  3. Mannitol oxidation in two Micromonospora isolates and in representative species of other actinomycetes. Mehta, R.J., Fare, L.R., Shearer, M.E., Nash, C.H. Appl. Environ. Microbiol. (1977) [Pubmed]
  4. Expression of a bacterial mtlD gene in transgenic tobacco leads to production and accumulation of mannitol. Tarczynski, M.C., Jensen, R.G., Bohnert, H.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Novel arguments in favor of the substrate-transport model of glucose-6-phosphatase. Gerin, I., Noël, G., Van Schaftingen, E. Diabetes (2001) [Pubmed]
  6. Mannitol-specific enzyme II of the bacterial phosphotransferase system. I. Properties of the purified permease. Jacobson, G.R., Lee, C.A., Leonard, J.E., Saier, M.H. J. Biol. Chem. (1983) [Pubmed]
  7. Mannitol 1-phosphate mediates an inhibitory effect of mannitol on the activity and the translocation of glucokinase in isolated rat hepatocytes. Niculescu, L., Van Schaftingen, E. Diabetologia (1998) [Pubmed]
  8. Corrected sequence of the mannitol (mtl) operon in Escherichia coli. Jiang, W., Wu, L.F., Tomich, J., Saier, M.H., Niehaus, W.G. Mol. Microbiol. (1990) [Pubmed]
  9. Conversion of D-mannitol to D-ribose: a newly discovered pathway in Escherichia coli. Rosenberg, H., Hardy, C.M. J. Bacteriol. (1984) [Pubmed]
  10. Mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Enterococcus faecalis: molecular cloning and nucleotide sequences of the enzyme IIIMtl gene and the mannitol-1-phosphate dehydrogenase gene, expression in Escherichia coli, and comparison of the gene products with similar enzymes. Fischer, R., von Strandmann, R.P., Hengstenberg, W. J. Bacteriol. (1991) [Pubmed]
  11. Kinetics and subunit interaction of the mannitol-specific enzyme II of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system. Roossien, F.F., Blaauw, M., Robillard, G.T. Biochemistry (1984) [Pubmed]
  12. Details of mannitol transport in Escherichia coli elucidated by site-specific mutagenesis and complementation of phosphorylation site mutants of the phosphoenolpyruvate-dependent mannitol-specific phosphotransferase system. van Weeghel, R.P., van der Hoek, Y.Y., Pas, H.H., Elferink, M., Keck, W., Robillard, G.T. Biochemistry (1991) [Pubmed]
  13. Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system. Honeyman, A.L., Curtiss, R. Infect. Immun. (1992) [Pubmed]
  14. Mutations affecting transport of the hexitols D-mannitol, D-glucitol, and galactitol in Escherichia coli K-12: isolation and mapping. Lengeler, J. J. Bacteriol. (1975) [Pubmed]
  15. Use of cloned mtl genes of Escherichia coli to introduce mtl deletion mutations into the chromosome. Lee, C.A., Saier, M.H. J. Bacteriol. (1983) [Pubmed]
  16. Stereochemical course of the reactions catalyzed by the bacterial phosphoenolpyruvate:mannitol phosphotransferase system. Mueller, E.G., Khandekar, S.S., Knowles, J.R., Jacobson, G.R. Biochemistry (1990) [Pubmed]
  17. Disturbance in the allocation of carbohydrates to regenerative organs in transgenic Nicotiana tabacum L. Sheveleva, E.V., Jensen, R.G., Bohnert, H.J. J. Exp. Bot. (2000) [Pubmed]
  18. Genetic relationships among the oral streptococci. Gilmour, M.N., Whittam, T.S., Kilian, M., Selander, R.K. J. Bacteriol. (1987) [Pubmed]
  19. Enzymatic properties, renaturation and metabolic role of mannitol-1-phosphate dehydrogenase from Escherichia coli. Teschner, W., Serre, M.C., Garel, J.R. Biochimie (1990) [Pubmed]
  20. Enhanced tolerance to salt stress in transgenic loblolly pine simultaneously expressing two genes encoding mannitol-1-phosphate dehydrogenase and glucitol-6-phosphate dehydrogenase. Tang, W., Peng, X., Newton, R.J. Plant Physiol. Biochem. (2005) [Pubmed]
  21. Purification and properties of D-mannitol-1-phosphate dehydrogenase and D-glucitol-6-phosphate dehydrogenase from Escherichia coli. Novotny, M.J., Reizer, J., Esch, F., Saier, M.H. J. Bacteriol. (1984) [Pubmed]
  22. The distribution of the NADPH regenerating mannitol cycle among fungal species. Hult, K., Veide, A., Gatenbeck, S. Arch. Microbiol. (1980) [Pubmed]
  23. Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides. Schneider, K.H., Giffhorn, F., Kaplan, S. J. Gen. Microbiol. (1993) [Pubmed]
  24. Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase: evidence for a very divergent long-chain dehydrogenase family. Kavanagh, K.L., Klimacek, M., Nidetzky, B., Wilson, D.K. Chem. Biol. Interact. (2003) [Pubmed]
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