Disease relevance of entD

• The entD gene was cloned on a 2.0-kilobase DNA fragment and was expressed in Escherichia coli [1].
• Isolation and characterization of Bacillus subtilis genes involved in siderophore biosynthesis: relationship between B. subtilis sfpo and Escherichia coli entD genes [2].

High impact information on entD

• Pyochelin formation was also obtained in the heterologous host Escherichia coli expressing pchDCBA and pchEFG together with the E. coli entD gene, which provides a phosphopantetheinyl transferase necessary for PchE and PchF activation [3].
• The Escherichia coli entD gene, which encodes a PPTase involved in biosynthesis of enterobactin (a siderophore), restored biosynthesis of albicidin (a DNA replication inhibitor) in X. albilineans Tox- LS156 (xabA::Tn5) [4].
• One set contained DNA sequences that complemented only an entD mutation [2].
• One gene was identified as sfpo, a previously reported gene involved in the production of surfactin in B. subtilis and which is highly homologous to the E. coli entD gene [2].
• AB. subtilis mutant containing an insertion in the region of the entD homolog grew much more poorly in low-iron medium and with markedly different kinetics [2].

Chemical compound and disease context of entD

• Biosynthesis of enterochelin in Escherichia coli K-12: separation of the polypeptides coded for by the entD, E, F and G genes [5].

Biological context of entD

• The gene (entD) encoding staphylococcal enterotoxin D (SED) has been located on a 27.6-kilobase penicillinase plasmid designated pIB485 [1].
• A further restriction fragment, carrying the three remaining genes, entD, fes and entF was cloned directly from the chromosome [6].

References