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Gene Review

entD  -  phosphopantetheinyltransferase component...

Escherichia coli UTI89

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Disease relevance of entD


High impact information on entD

  • Pyochelin formation was also obtained in the heterologous host Escherichia coli expressing pchDCBA and pchEFG together with the E. coli entD gene, which provides a phosphopantetheinyl transferase necessary for PchE and PchF activation [3].
  • The Escherichia coli entD gene, which encodes a PPTase involved in biosynthesis of enterobactin (a siderophore), restored biosynthesis of albicidin (a DNA replication inhibitor) in X. albilineans Tox- LS156 (xabA::Tn5) [4].
  • One set contained DNA sequences that complemented only an entD mutation [2].
  • One gene was identified as sfpo, a previously reported gene involved in the production of surfactin in B. subtilis and which is highly homologous to the E. coli entD gene [2].
  • AB. subtilis mutant containing an insertion in the region of the entD homolog grew much more poorly in low-iron medium and with markedly different kinetics [2].

Chemical compound and disease context of entD


Biological context of entD

  • The gene (entD) encoding staphylococcal enterotoxin D (SED) has been located on a 27.6-kilobase penicillinase plasmid designated pIB485 [1].
  • A further restriction fragment, carrying the three remaining genes, entD, fes and entF was cloned directly from the chromosome [6].


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