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Gene Review

ompA  -  outer membrane protein OmpA

Escherichia coli UTI89

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Disease relevance of ompA


High impact information on ompA

  • Effects of ompA Deletion on Expression of Type 1 Fimbriae in Escherichia coli K1 Strain RS218 and on the Association of E. coli with Human Brain Microvascular Endothelial Cells [4].
  • Although close spacing of translating ribosomes is not critical for message stabilization by the ompA 5' UTR, mRNA longevity does require the periodic passage of ribosomes through the protein-coding region [5].
  • These findings imply that the ompA 5' UTR prolongs mRNA longevity by impeding multiple pathways for mRNA degradation [5].
  • This was 50% higher than the best result obtained from plasmid construct lacUV5par8cex, using the lacUV5 promoter and the ompA leader sequence [6].
  • Regulation of ompA by micA may have been retained due to a necessity for ompA control during one or both stages of the P. luminescens life cycle [7].

Biological context of ompA

  • Furthermore, real-time PCR analysis indicates that the extent of polyadenylation of individual full-length transcripts such as lpp and ompA varies significantly in wild-type cells [8].

Analytical, diagnostic and therapeutic context of ompA


  1. Copurification of E. coli RNAase E and PNPase: evidence for a specific association between two enzymes important in RNA processing and degradation. Carpousis, A.J., Van Houwe, G., Ehretsmann, C., Krisch, H.M. Cell (1994) [Pubmed]
  2. A Naturally Occurring Novel Allele of Escherichia coli Outer Membrane Protein A Reduces Sensitivity to Bacteriophage. Power, M.L., Ferrari, B.C., Littlefield-Wyer, J., Gordon, D.M., Slade, M.B., Veal, D.A. Appl. Environ. Microbiol. (2006) [Pubmed]
  3. The Acinetobacter outer membrane protein A (OmpA) is a secreted emulsifier. Walzer, G., Rosenberg, E., Ron, E.Z. Environ. Microbiol. (2006) [Pubmed]
  4. Effects of ompA Deletion on Expression of Type 1 Fimbriae in Escherichia coli K1 Strain RS218 and on the Association of E. coli with Human Brain Microvascular Endothelial Cells. Teng, C.H., Xie, Y., Shin, S., Di Cello, F., Paul-Satyaseela, M., Cai, M., Kim, K.S. Infect. Immun. (2006) [Pubmed]
  5. mRNA stabilization by the ompA 5' untranslated region: two protective elements hinder distinct pathways for mRNA degradation. Arnold, T.E., Yu, J., Belasco, J.G. RNA (1998) [Pubmed]
  6. A two-stage refinement approach for the enhancement of excretory production of an exoglucanase from Escherichia coli. Fu, Z.B., Ng, K.L., Lam, C.C., Leung, K.C., Yip, W.H., Wong, W.K. Protein Expr. Purif. (2006) [Pubmed]
  7. Outer membrane protein genes and their small non-coding RNA regulator genes in Photorhabdus luminescens. Papamichail, D., Delihas, N. Biology direct [electronic resource]. (2006) [Pubmed]
  8. The majority of Escherichia coli mRNAs undergo post-transcriptional modification in exponentially growing cells. Mohanty, B.K., Kushner, S.R. Nucleic Acids Res. (2006) [Pubmed]
  9. Expression and purification of native human granulocyte-macrophage colony-stimulating factor from an Escherichia coli secretion vector. Libby, R.T., Braedt, G., Kronheim, S.R., March, C.J., Urdal, D.L., Chiaverotti, T.A., Tushinski, R.J., Mochizuki, D.Y., Hopp, T.P., Cosman, D. DNA (1987) [Pubmed]
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