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Gene Review

rdgC  -  retinal degeneration C

Drosophila melanogaster

Synonyms: CG13814, CG44746, CG6571, Dmel\CG44746, Dmel_CG13814, ...
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Disease relevance of rdgC


High impact information on rdgC


Chemical compound and disease context of rdgC


Biological context of rdgC


Anatomical context of rdgC


Other interactions of rdgC

  • In contrast, no decrease was observed in the amounts of Rh1 metarhodopsin recovered from illuminated flies which were deficient either in the eye-specific phosphatase (rdgC mutant) or in the eye-specific phospholipase C (norpA(H24) and norpA(H52) mutants) [8].


  1. Regulation of the rhodopsin protein phosphatase, RDGC, through interaction with calmodulin. Lee, S.J., Montell, C. Neuron (2001) [Pubmed]
  2. Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase. Steele, F.R., Washburn, T., Rieger, R., O'Tousa, J.E. Cell (1992) [Pubmed]
  3. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants. Davidson, F.F., Steller, H. Nature (1998) [Pubmed]
  4. A G protein-coupled receptor phosphatase required for rhodopsin function. Vinós, J., Jalink, K., Hardy, R.W., Britt, S.G., Zuker, C.S. Science (1997) [Pubmed]
  5. A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin. Montini, E., Rugarli, E.I., Van de Vosse, E., Andolfi, G., Mariani, M., Puca, A.A., Consalez, G.G., den Dunnen, J.T., Ballabio, A., Franco, B. Hum. Mol. Genet. (1997) [Pubmed]
  6. Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. Sherman, P.M., Sun, H., Macke, J.P., Williams, J., Smallwood, P.M., Nathans, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Rhodopsin activation causes retinal degeneration in Drosophila rdgC mutant. Steele, F., O'Tousa, J.E. Neuron (1990) [Pubmed]
  8. Studies of Rh1 metarhodopsin stabilization in wild-type Drosophila and in mutants lacking one or both arrestins. Kiselev, A., Subramaniam, S. Biochemistry (1997) [Pubmed]
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