Disease relevance of MLANA

• We conclude that Melan A is a specific and sensitive marker for canine melanomas [1].
• Comparison of tyrosinase-related protein-2, S-100, and Melan A immunoreactivity in canine amelanotic melanomas [2].
• Following complete excision of the mass, a diagnosis of sebaceous adenocarcinoma was made based on histologic features, positive immunostaining for pancytokeratin, and negative staining for vimentin, Melan-A, and S-100 [3].

High impact information on MLANA

• By immunohistochemistry, neoplastic cells stained positively for cytokeratin (29 of 29), vimentin (28 of 28), S-100 protein (24 of 29), and melan A (8 of 12); results were negative for smooth muscle actin and calponin in all cases [4].
• Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma [5].
• We evaluated the expression of vimentin, S100a, and Melan A/MART-1 (melanoma antigen recognized by T cells 1) in seven cell lines established independently from dogs with canine melanoma [5].
• Our results suggest that expression of Melan A/MART-1 may be unstable in cultured cell lines [5].
• Cytologic evaluation of the eye and lymph node were performed following aqueocentesis and fine-needle aspiration, respectively.The affected lymph node was examined histologically and stained for cytokeratin, vimentin, S-100, and Melan A [6].

Biological context of MLANA

• The presence of metastatic melanoma cells was confirmed by cytological examination and reverse transcription polymerase chain reaction (RT-PCR) using primers for the melanoma-associated antigens: tyrosinase and mart-1/melan A [7].

Anatomical context of MLANA

• The immunocytochemical staining results of the canine melanomas and the regional lymph nodes showed high conformity with the immunohistochemical reactivity patterns for S-100 and Melan-A [8].

Analytical, diagnostic and therapeutic context of MLANA

• Immunohistochemistry revealed an intense labelling of tumour cells for vimentin, and a partial labelling for neuron-specific enolase, S100 protein, and Melan-A [9].

References