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Gene Review

MLANA  -  melan-A

Canis lupus familiaris

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Disease relevance of MLANA


High impact information on MLANA


Biological context of MLANA


Anatomical context of MLANA

  • The immunocytochemical staining results of the canine melanomas and the regional lymph nodes showed high conformity with the immunohistochemical reactivity patterns for S-100 and Melan-A [8].

Analytical, diagnostic and therapeutic context of MLANA

  • Immunohistochemistry revealed an intense labelling of tumour cells for vimentin, and a partial labelling for neuron-specific enolase, S100 protein, and Melan-A [9].


  1. Retrospective study of 338 canine oral melanomas with clinical, histologic, and immunohistochemical review of 129 cases. Ramos-Vara, J.A., Beissenherz, M.E., Miller, M.A., Johnson, G.C., Pace, L.W., Fard, A., Kottler, S.J. Vet. Pathol. (2000) [Pubmed]
  2. Comparison of tyrosinase-related protein-2, S-100, and Melan A immunoreactivity in canine amelanotic melanomas. Choi, C., Kusewitt, D.F. Vet. Pathol. (2003) [Pubmed]
  3. Cutaneous mass aspirate from a Golden Retriever: "glandular guile". Dickinson, R.M., Young, K.M. Veterinary clinical pathology / American Society for Veterinary Clinical Pathology. (2005) [Pubmed]
  4. Canine cutaneous clear cell adnexal carcinoma: histopathology, immunohistochemistry, and biologic behavior of 26 cases. Schulman, F.Y., Lipscomb, T.P., Atkin, T.J. J. Vet. Diagn. Invest. (2005) [Pubmed]
  5. Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma. Koenig, A., Wojcieszyn, J., Weeks, B.R., Modiano, J.F. Vet. Pathol. (2001) [Pubmed]
  6. Metastatic balloon cell melanoma in a dog. Wilkerson, M.J., Dolce, K., DeBey, B.M., Heeb, H., Davidson, H. Veterinary clinical pathology / American Society for Veterinary Clinical Pathology. (2003) [Pubmed]
  7. Immunosuppressive cytokines in the regional lymph node of a dog suffering from oral malignant melanoma. Catchpole, B., Gould, S.M., Kellett-Gregory, L.M., Dobson, J.M. The Journal of small animal practice. (2002) [Pubmed]
  8. Use of immunocytochemical techniques in canine melanoma. Höinghaus, R., Mischke, R., Hewicker-Trautwein, M. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. (2002) [Pubmed]
  9. Primary endocardial malignant spindle-cell sarcoma in the right atrium of a dog resembling a malignant peripheral nerve sheath tumour. Wohlsein, P., Cichowski, S., Baumgärtner, W. J. Comp. Pathol. (2005) [Pubmed]
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