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MeSH Review

Melanoma, Amelanotic

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Disease relevance of Melanoma, Amelanotic


High impact information on Melanoma, Amelanotic


Chemical compound and disease context of Melanoma, Amelanotic

  • The isolated fractions consisting of necrotic tumor cells and inflammatory cells (alpha fraction) apparently contain a cysteine proteinase inhibitor, since both cathepsin B-like and cathepsin H activities in the beta fraction of B16 amelanotic melanomas could be inhibited by addition of the alpha fraction [11].
  • In order to resolve this controversy, the alpha IIb beta 3-like integrin in murine B16 amelanotic melanoma (B16a) cells was characterized at DNA, RNA, and protein levels [12].
  • Exposure to hyperoxia generally failed to induce either the activity of GSH peroxidase (GPx) or the manganese-containing form of superoxide dismutase (MnSOD) after 48 h, although at 605 mm Hg oxygen, small inductions of MnSOD activity were observed in adult lung fibroblasts and amelanotic melanoma [13].
  • We first investigated the effects of cell source and culture conditions on lung colony formation by i.v. injected B16a (B16 amelanotic melanoma) cells and inhibition of tumor colony formation by the thromboxane A2 synthase inhibitor, CGS14854 [14].
  • Using an amelanotic melanoma (A-Mel-3) grown subcutaneously in Syrian Golden hamsters, we confirmed these results in vivo: tumor growth was markedly delayed in animals treated with 100 mg/kg 5-aminolevulinic acid intravenously and irradiated with coherent light at 635 nm as compared to animals irradiated at 630 nm [15].

Biological context of Melanoma, Amelanotic


Anatomical context of Melanoma, Amelanotic


Gene context of Melanoma, Amelanotic

  • Both c-Kit (expressed in superficial spreading disease) and VEGF (expressed in amelanotic melanoma) may have significant therapeutic implications as molecular targets, which warrants further investigation [24].
  • However, ABCB 5alpha/beta expression was undetectable in two amelanotic melanomas (M14 and LOX-IMVI) [25].
  • In addition, there are some kinds of human amelanotic melanomas, such as MEL2A, in which expression of tyrosinase is repressed or lacking though tyrosinase-related protein (TRP)-1 and TRP-2 are well expressed [26].
  • A protocol was developed to distinguish between initial tumor-cell (B16 amelanotic melanoma; B16a) adhesion to and spreading on fibronectin [27].
  • We have cloned the tryptophan hydroxylase cDNA from hamster pituitary and demonstrated its expression in the skin, melanotic and amelanotic melanomas, spleen, heart, and the eye [28].

Analytical, diagnostic and therapeutic context of Melanoma, Amelanotic


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  9. 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Liu, B., Khan, W.A., Hannun, Y.A., Timar, J., Taylor, J.D., Lundy, S., Butovich, I., Honn, K.V. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  10. Inhibitory activity of human lactoferrin and its peptide on chondroitin sulfate A-, CD36-, and thrombospondin-mediated cytoadherence of plasmodium falciparum-infected erythrocytes. Eda, S., Eda, K., Prudhomme, J.G., Sherman, I.W. Blood (1999) [Pubmed]
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  13. Effects of oxygen on the antioxidant responses of normal and transformed cells. Allen, R.G., Balin, A.K. Exp. Cell Res. (2003) [Pubmed]
  14. Phenotypic properties of cultured tumor cells: integrin alpha IIb beta 3 expression, tumor-cell-induced platelet aggregation, and tumor-cell adhesion to endothelium as important parameters of experimental metastasis. Tang, D.G., Onoda, J.M., Steinert, B.W., Grossi, I.M., Nelson, K.K., Umbarger, L., Diglio, C.A., Taylor, J.D., Honn, K.V. Int. J. Cancer (1993) [Pubmed]
  15. Wavelength dependency of photodynamic effects after sensitization with 5-aminolevulinic acid in vitro and in vivo. Szeimies, R.M., Abels, C., Fritsch, C., Karrer, S., Steinbach, P., Bäumler, W., Goerz, G., Goetz, A.E., Landthaler, M. J. Invest. Dermatol. (1995) [Pubmed]
  16. Platinum complex cytotoxicity tested by the electrical resistance breakdown assay. Ludwig, T., Fakih, S., Krebs, B., Oberleithner, H. Cell. Physiol. Biochem. (2004) [Pubmed]
  17. Molecular and biological control of melanogenesis through tyrosinase genes and intrinsic and extrinsic regulatory factors. Mishima, Y. Pigment Cell Res. (1994) [Pubmed]
  18. The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. Schallreuter, K.U., Gleason, F.K., Wood, J.M. Biochim. Biophys. Acta (1990) [Pubmed]
  19. Properties of a plasma membrane-associated cathepsin B-like cysteine proteinase in metastatic B16 melanoma variants. Rozhin, J., Robinson, D., Stevens, M.A., Lah, T.T., Honn, K.V., Ryan, R.E., Sloane, B.F. Cancer Res. (1987) [Pubmed]
  20. Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process. Tang, D.G., Diglio, C.A., Honn, K.V. Cancer Res. (1994) [Pubmed]
  21. Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway. Halaban, R., Patton, R.S., Cheng, E., Svedine, S., Trombetta, E.S., Wahl, M.L., Ariyan, S., Hebert, D.N. J. Biol. Chem. (2002) [Pubmed]
  22. Inhibition of melanin synthesis by cystamine in human melanoma cells. Qiu, L., Zhang, M., Sturm, R.A., Gardiner, B., Tonks, I., Kay, G., Parsons, P.G. J. Invest. Dermatol. (2000) [Pubmed]
  23. Comparison of tyrosinase levels in amelanotic and melanotic melanoma cell cultures by a competitive enzyme-linked immunoadsorbent assay and by immunotitration analysis. Fuller, B.B., Iman, D.S., Lunsford, J.B. J. Cell. Physiol. (1988) [Pubmed]
  24. Immunohistochemical determination of HER-2/neu, c-Kit (CD117), and vascular endothelial growth factor (VEGF) overexpression in malignant melanoma. Potti, A., Moazzam, N., Langness, E., Sholes, K., Tendulkar, K., Koch, M., Kargas, S. J. Cancer Res. Clin. Oncol. (2004) [Pubmed]
  25. Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. Chen, K.G., Szakács, G., Annereau, J.P., Rouzaud, F., Liang, X.J., Valencia, J.C., Nagineni, C.N., Hooks, J.J., Hearing, V.J., Gottesman, M.M. Pigment Cell Res. (2005) [Pubmed]
  26. Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. Tsuboi, T., Kondoh, H., Hiratsuka, J., Mishima, Y. Pigment Cell Res. (1998) [Pubmed]
  27. The lipoxygenase metabolite 12(S)-HETE promotes alpha IIb beta 3 integrin-mediated tumor-cell spreading on fibronectin. Timar, J., Chen, Y.Q., Liu, B., Bazaz, R., Taylor, J.D., Honn, K.V. Int. J. Cancer (1992) [Pubmed]
  28. Serotoninergic system in hamster skin. Slominski, A., Pisarchik, A., Semak, I., Sweatman, T., Szczesniewski, A., Wortsman, J. J. Invest. Dermatol. (2002) [Pubmed]
  29. Amelanotic melanoma: cases studied by Fontana stain, S-100 immunostain, and ultrastructural examination. Gibson, L.E., Goellner, J.R. Mayo Clin. Proc. (1988) [Pubmed]
  30. Carcinoembryonic antigen. Its role in the evaluation of intraocular malignant tumors. Michelson, J.B., Felberg, N.T., Shields, J.A. Arch. Ophthalmol. (1976) [Pubmed]
  31. Membrane-associated cathepsin L: a role in metastasis of melanomas. Rozhin, J., Wade, R.L., Honn, K.V., Sloane, B.F. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  32. Combination chemotherapy with cisplatin and nifedipine: synergistic antitumor effects against a cisplatin-resistant subline of the B16 amelanotic melanoma. Onoda, J.M., Nelson, K.K., Pilarski, S.M., White, N.S., Mihu, R.G., Honn, K.V. Clin. Exp. Metastasis (1990) [Pubmed]
  33. A primary amelanotic melanoma of the vagina, diagnosed by immunohistochemical staining with HMB-45, which recurred as a pigmented melanoma. Oguri, H., Izumiya, C., Maeda, N., Fukaya, T., Moriki, T. J. Clin. Pathol. (2004) [Pubmed]
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