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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FABP1  -  fatty acid binding protein 1, liver

Canis lupus familiaris

 
 
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Disease relevance of FABP1

  • No significant differences in the effects of chemical anoxia or oleate were observed between non-transfected, mock-transfected and FABP-cDNA-transfected cells [1].
 

High impact information on FABP1

  • Cardiac myocytes contain a basic (pI approximately 9.1) 40-kD plasma membrane fatty acid binding protein (FABPPM) analogous to those recently isolated from liver, adipose tissue, and gut, unrelated to the 12-14-kD cytosolic FABP in these same tissues [2].
  • We studied the effects of transfection with cDNA encoding heart FABP, adipocyte FABP or liver FABP on cytotoxicity induced by chemical anoxia or FAs [1].
  • Non-esterified FA accumulation was not reduced in any of the FABP-cDNA-transfected cell lines [1].
  • Transfection of MDCK type II cells with these cDNA types caused a 5-20-fold increase in FABP content, but did not change the rate or extent of palmitate uptake [1].

References

  1. Fatty-acid-binding proteins do not protect against induced cytotoxicity in a kidney cell model. Zimmerman, A.W., Veerkamp, J.H. Biochem. J. (2001) [Pubmed]
  2. Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut. Sorrentino, D., Stump, D., Potter, B.J., Robinson, R.B., White, R., Kiang, C.L., Berk, P.D. J. Clin. Invest. (1988) [Pubmed]
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