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Gene Review

Fabp1  -  fatty acid binding protein 1, liver

Mus musculus

Synonyms: 14 kDa selenium-binding protein, Fabpl, Fatty acid-binding protein 1, Fatty acid-binding protein, liver, L-FABP, ...
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Disease relevance of Fabp1


High impact information on Fabp1

  • To determine whether the slowed migration was a direct effect of forced expression of E-cadherin or a secondary effect of reduced crypt cell production, another Fabp promoter was used to restrict overproduction of E-cadherin to the villus epithelium of transgenic mice [6].
  • Transgenes consisting of segments of the rat liver fatty acid-binding protein (L-FABP) gene's 5' non-transcribed domain linked to the human growth hormone (hGH) gene (minus its regulatory elements) have provided useful tools for analyzing the mechanisms that regulate cellular and spatial differentiation of the continuously renewing gut epithelium [7].
  • Immunocytochemical analysis of isografts harvested 4-6 wk after implantation revealed that activation of the intact endogenous mouse L-FABP gene (fabpl) in differentiating enterocytes is perfectly recapitulated as these cells are translocated along the crypt-to-villus axis [7].
  • In the present study, we have used immunocytochemical techniques to map the distribution of enteroendocrine cells in the normal adult mouse gut and to characterize those that synthesize L-FABP [8].
  • Young (5-7 weeks) mice containing a L-FABP (-4000 to +21)/hGH transgene also demonstrated inappropriate expression of the transgene in most proximal colonic crypts [9].

Chemical compound and disease context of Fabp1


Biological context of Fabp1


Anatomical context of Fabp1


Associations of Fabp1 with chemical compounds

  • Here we show first that phytanic acid binds to recombinant L-FABP with high affinity [1].
  • This issue was addressed by examining the response of young (7 wk) female mice to L-FABP gene ablation and a cholesterol-rich diet [2].
  • In contrast, high-affinity LCFA-CoA binding was absent from Fraction III of L-FABP (-/-) mice [10].
  • A cis-parinaric acid displacement assay showed that L-FABP bound BODIPY-C12 and BODIPY-C16 with K(i)s of 10.1 +/- 2.5 and 20.7 +/- 1.5 nM, respectively, in the same range as naturally occurring LCFAs [16].
  • Nevertheless, the soluble fraction from livers of L-FABP (-/-) mice bound 95% less radioactive oleoyl-CoA than wild-type L-FABP (+/+) mice [10].

Physical interactions of Fabp1


Regulatory relationships of Fabp1


Other interactions of Fabp1


Analytical, diagnostic and therapeutic context of Fabp1

  • Finally, solid-phase extraction and HPLC analysis revealed that, depending on the fatty acid content of the culture medium, L-FABP expression also increased the cellular LCFA-CoA pool size and altered the LCFA-CoA acyl chain composition [16].
  • The intracellular LCFA-CoA binding protein fraction (Fraction III) from wild-type L-FABP (+/+) mice, isolated by gel permeation chromatography of liver soluble proteins, exhibited one high-affinity binding and several low-affinity binding sites for cis-parinaroyl-CoA, a naturally occurring fluorescent LCFA-CoA [10].
  • The 90-kDa protein also binds to an element in the matrix metalloproteinase-2 gene that functions as an enhancer in renal cells, shares sequence homology with the heptad, and generates similar-sized complexes in gel mobility shift assays as the Fabpl repeat [23].
  • In this case, LFABP mRNA levels decreased more slowly after partial hepatectomy than in rats [4].
  • Stable transfectant cell lines were selected and expression of L-FABP determined using Western blot analysis [24].


  1. Phytanic acid is ligand and transcriptional activator of murine liver fatty acid binding protein. Wolfrum, C., Ellinghaus, P., Fobker, M., Seedorf, U., Assmann, G., Börchers, T., Spener, F. J. Lipid Res. (1999) [Pubmed]
  2. Liver fatty acid binding protein gene ablation potentiates hepatic cholesterol accumulation in cholesterol-fed female mice. Martin, G.G., Atshaves, B.P., McIntosh, A.L., Mackie, J.T., Kier, A.B., Schroeder, F. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  3. Expression of fatty acid binding proteins inhibits lipid accumulation and alters toxicity in L cell fibroblasts. Atshaves, B.P., Storey, S.M., Petrescu, A., Greenberg, C.C., Lyuksyutova, O.I., Smith, R., Schroeder, F. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  4. Decreased expression of peroxisome proliferator-activated receptor alpha and liver fatty acid binding protein after partial hepatectomy of rats and mice. Skrtic, S., Carlsson, L., Ljungberg, A., Lindén, D., Michalik, L., Wahli, W., Oscarsson, J. Liver Int. (2005) [Pubmed]
  5. Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Newberry, E.P., Xie, Y., Kennedy, S.M., Luo, J., Davidson, N.O. Hepatology (2006) [Pubmed]
  6. Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system. Hermiston, M.L., Wong, M.H., Gordon, J.I. Genes Dev. (1996) [Pubmed]
  7. Epithelial cell differentiation in normal and transgenic mouse intestinal isografts. Rubin, D.C., Roth, K.A., Birkenmeier, E.H., Gordon, J.I. J. Cell Biol. (1991) [Pubmed]
  8. Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract. Roth, K.A., Hertz, J.M., Gordon, J.I. J. Cell Biol. (1990) [Pubmed]
  9. Temporal and spatial patterns of transgene expression in aging adult mice provide insights about the origins, organization, and differentiation of the intestinal epithelium. Cohn, S.M., Roth, K.A., Birkenmeier, E.H., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. Ablation of the liver fatty acid binding protein gene decreases fatty acyl CoA binding capacity and alters fatty acyl CoA pool distribution in mouse liver. Martin, G.G., Huang, H., Atshaves, B.P., Binas, B., Schroeder, F. Biochemistry (2003) [Pubmed]
  11. Fibroblast membrane sterol kinetic domains: modulation by sterol carrier protein-2 and liver fatty acid binding protein. Frolov, A., Woodford, J.K., Murphy, E.J., Billheimer, J.T., Schroeder, F. J. Lipid Res. (1996) [Pubmed]
  12. Liver fatty acid binding protein expression enhances branched-chain fatty acid metabolism. Atshaves, B.P., Storey, S.M., Huang, H., Schroeder, F. Mol. Cell. Biochem. (2004) [Pubmed]
  13. Linkage of the murine transforming growth factor alpha gene with Igk, Ly-2, and Fabp1 on chromosome 6. Fowler, K.J., Mann, G.B., Dunn, A.R. Genomics (1993) [Pubmed]
  14. Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice. Erol, E., Kumar, L.S., Cline, G.W., Shulman, G.I., Kelly, D.P., Binas, B. FASEB J. (2004) [Pubmed]
  15. Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene. Martin, G.G., Danneberg, H., Kumar, L.S., Atshaves, B.P., Erol, E., Bader, M., Schroeder, F., Binas, B. J. Biol. Chem. (2003) [Pubmed]
  16. Liver fatty acid-binding protein colocalizes with peroxisome proliferator activated receptor alpha and enhances ligand distribution to nuclei of living cells. Huang, H., Starodub, O., McIntosh, A., Atshaves, B.P., Woldegiorgis, G., Kier, A.B., Schroeder, F. Biochemistry (2004) [Pubmed]
  17. L-FABP is exclusively expressed in alveolar macrophages within the myeloid lineage: evidence for a PPARalpha-independent expression. Schachtrup, C., Scholzen, T.E., Grau, V., Luger, T.A., Sorg, C., Spener, F., Kerkhoff, C. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  18. Analysis of tissue-specific and PPARalpha-dependent induction of FABP gene expression in the mouse liver by an in vivo DNA electroporation method. Fujishiro, K., Fukui, Y., Sato, O., Kawabe, K., Seto, K., Motojima, K. Mol. Cell. Biochem. (2002) [Pubmed]
  19. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. Poirier, H., Niot, I., Monnot, M.C., Braissant, O., Meunier-Durmort, C., Costet, P., Pineau, T., Wahli, W., Willson, T.M., Besnard, P. Biochem. J. (2001) [Pubmed]
  20. Liver and intestinal fatty acid binding proteins in control and TGF beta 1 gene targeted deficient mice. Fontaine, R.N., Gossett, R.E., Schroeder, F., O'Toole, B.A., Doetschman, T., Kier, A.B. Mol. Cell. Biochem. (1996) [Pubmed]
  21. Genetic mapping of the lurcher locus on mouse chromosome 6 using an intersubspecific backcross. Norman, D.J., Fletcher, C., Heintz, N. Genomics (1991) [Pubmed]
  22. Adaptations to the loss of intestinal fatty acid binding protein in mice. Agellon, L.B., Li, L., Luong, L., Uwiera, R.R. Mol. Cell. Biochem. (2006) [Pubmed]
  23. Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. Simon, T.C., Cho, A., Tso, P., Gordon, J.I. J. Biol. Chem. (1997) [Pubmed]
  24. Altered membrane structure in transfected mouse L-cell fibroblasts expressing rat liver fatty acid-binding protein. Jefferson, J.R., Powell, D.M., Rymaszewski, Z., Kukowska-Latallo, J., Lowe, J.B., Schroeder, F. J. Biol. Chem. (1990) [Pubmed]
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