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Gene Review

Fabp1  -  fatty acid binding protein 1, liver

Rattus norvegicus

Synonyms: Fabplg, Fatty acid-binding protein 1, Fatty acid-binding protein, liver, L-FABP, Liver-type fatty acid-binding protein, ...
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Disease relevance of Fabp1


High impact information on Fabp1


Chemical compound and disease context of Fabp1


Biological context of Fabp1


Anatomical context of Fabp1

  • Photoaffinity labeling and protection experiments carried out on purified preparations of L-FABP paralleled the labeling results obtained in the microsomes and cytosol, confirming that L-FABP is capable of specifically binding AzBHC, warfarin, and dicoumarol [16].
  • Furthermore, no alteration in the relative level of SCP mRNA associated with polysomes or in polysome size occurs at the maximum and minimum points of SCP synthesis [17].
  • These results demonstrate that the alpha-helical region of LFABP is responsible for its diffusional mechanism of fatty acid transfer to membranes [18].
  • The complete sequence of Z-protein showed striking homology to cellular retinoid binding proteins and peripheral nerve myelin P2 protein, which indicated the presence of a new family of cellular lipid-binding proteins diverged from a common ancestor [19].
  • Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes [15].

Associations of Fabp1 with chemical compounds


Physical interactions of Fabp1

  • Binding and proximity relationships of fatty acids with recombinant rat liver fatty acid-binding protein (L-FABP) and intestinal fatty acid-binding protein (I-FABP) were studied with absorption and fluorescence spectroscopy [20].
  • Quartz-crystal microbalance analysis revealed that L-FABP bound to megalin, a multiligand endocytotic receptor on PTC, in a Ca2+-dependent manner [21].

Other interactions of Fabp1

  • Intestinal fatty acid binding protein (IFABP) and liver FABP (LFABP), homologous proteins expressed at high levels in intestinal absorptive cells, employ markedly different mechanisms for the transfer of fatty acids (FAs) to acceptor membranes [18].
  • Although Crabp2 had been identified as one of the 16 genes differentially expressed between ACI and BUF rats with cDNA-RDA, Fabp1 and Ugt2b5 were newly identified in this study [22].
  • PPAR alpha agonists increased the expression and biosynthesis of liver fatty acid-binding protein (LFABP) [23].
  • Electrophoretic mobility-shift assay revealed that both PPARalpha-RXRalpha and PPARdelta-RXRalpha heterodimers, specifically and in a dose-dependent manner, bound to the two PPRE-like elements of the rat CRBPII gene as well as the known PPREs in the L-FABP and acyl-CoA oxidase genes [24].
  • We have reported that dietary long-chain triacylglycerols (LCT) enhance the transcription of cellular retinol-binding protein, the type II (CRBPII) gene, and the liver-type fatty acid-binding protein (L-FABP) gene in the small intestine [24].

Analytical, diagnostic and therapeutic context of Fabp1


  1. Liver fatty acid binding protein is the mitosis-associated polypeptide target of a carcinogen in rat hepatocytes. Bassuk, J.A., Tsichlis, P.N., Sorof, S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Expression of rat intestinal fatty acid-binding protein in Escherichia coli. Purification and comparison of ligand binding characteristics with that of Escherichia coli-derived rat liver fatty acid-binding protein. Lowe, J.B., Sacchettini, J.C., Laposata, M., McQuillan, J.J., Gordon, J.I. J. Biol. Chem. (1987) [Pubmed]
  3. Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. Keler, T., Barker, C.S., Sorof, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Elevated expression and cell cycle deregulation of a mitosis-associated target polypeptide of a carcinogen in hyperplastic and malignant rat hepatocytes. Sorof, S., Custer, R.P. Cancer Res. (1987) [Pubmed]
  5. Liver fatty acid-binding protein: specific mediator of the mitogenesis induced by two classes of carcinogenic peroxisome proliferators. Khan, S.H., Sorof, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. Khan, S.H., Sorof, S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. Selective binding of cholesterol by recombinant fatty acid binding proteins. Nemecz, G., Schroeder, F. J. Biol. Chem. (1991) [Pubmed]
  8. Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 omega-hydroxylase pathway. Kaikaus, R.M., Chan, W.K., Lysenko, N., Ray, R., Ortiz de Montellano, P.R., Bass, N.M. J. Biol. Chem. (1993) [Pubmed]
  9. Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation. Nanji, A.A., Dannenberg, A.J., Jokelainen, K., Bass, N.M. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  10. Specific high affinity binding of lipoxygenase metabolites of arachidonic acid by liver fatty acid binding protein. Raza, H., Pongubala, J.R., Sorof, S. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  11. Ferriheme and ferroheme are isosteric inhibitors of fatty acid binding to rat liver fatty acid binding protein. Stewart, J.M., Slysz, G.W., Pritting, M.A., Muller-Eberhard, U. Biochem. Cell Biol. (1996) [Pubmed]
  12. The nucleotide sequence of the rat liver fatty acid-binding protein gene. Evidence that exon 1 encodes an oligopeptide domain shared by a family of proteins which bind hydrophobic ligands. Sweetser, D.A., Lowe, J.B., Gordon, J.I. J. Biol. Chem. (1986) [Pubmed]
  13. The effect of charge reversal mutations in the alpha-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids. Hagan, R.M., Davies, J.K., Wilton, D.C. Mol. Cell. Biochem. (2002) [Pubmed]
  14. Enhanced expression of cytosolic fatty acid binding protein and fatty acid uptake during liver regeneration in rats. Wang, G., Chen, Q.M., Minuk, G.Y., Gong, Y., Burczynski, F.J. Mol. Cell. Biochem. (2004) [Pubmed]
  15. Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes. Antonenkov, V.D., Sormunen, R.T., Ohlmeier, S., Amery, L., Fransen, M., Mannaerts, G.P., Hiltunen, J.K. Biochem. J. (2006) [Pubmed]
  16. Identification by photoaffinity labeling of fatty acid-binding protein as a potential warfarin receptor in rat liver. Myszka, D.G., Swenson, R.P. J. Biol. Chem. (1991) [Pubmed]
  17. Translational control of the circadian rhythm of liver sterol carrier protein. Analysis of mRNA sequences with a specific cDNA probe. McGuire, D.M., Chan, L., Smith, L.C., Towle, H.C., Dempsey, M.E. J. Biol. Chem. (1985) [Pubmed]
  18. The alpha-helical domain of liver fatty acid binding protein is responsible for the diffusion-mediated transfer of fatty acids to phospholipid membranes. Córsico, B., Liou, H.L., Storch, J. Biochemistry (2004) [Pubmed]
  19. Isolation and characterization of the three fractions (DE-I, DE-II and DE-III) of rat-liver Z-protein and the complete primary structure of DE-II. Takahashi, K., Odani, S., Ono, T. Eur. J. Biochem. (1983) [Pubmed]
  20. Polyene fatty acid interactions with recombinant intestinal and liver fatty acid-binding proteins. Spectroscopic studies. Nemecz, G., Jefferson, J.R., Schroeder, F. J. Biol. Chem. (1991) [Pubmed]
  21. Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules. Oyama, Y., Takeda, T., Hama, H., Tanuma, A., Iino, N., Sato, K., Kaseda, R., Ma, M., Yamamoto, T., Fujii, H., Kazama, J.J., Odani, S., Terada, Y., Mizuta, K., Gejyo, F., Saito, A. Lab. Invest. (2005) [Pubmed]
  22. Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays. Yamashita, S., Nomoto, T., Ohta, T., Ohki, M., Sugimura, T., Ushijima, T. Mamm. Genome (2003) [Pubmed]
  23. Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48. Lindén, D., Lindberg, K., Oscarsson, J., Claesson, C., Asp, L., Li, L., Gustafsson, M., Borén, J., Olofsson, S.O. J. Biol. Chem. (2002) [Pubmed]
  24. Modulation of the expression of peroxisome proliferator-activated receptor-dependent genes through disproportional expression of two subtypes in the small intestine. Mochizuki, K., Suruga, K., Kitagawa, M., Takase, S., Goda, T. Arch. Biochem. Biophys. (2001) [Pubmed]
  25. Fatty acid interactions with rat intestinal and liver fatty acid-binding proteins expressed in Escherichia coli. A comparative 13C NMR study. Cistola, D.P., Sacchettini, J.C., Banaszak, L.J., Walsh, M.T., Gordon, J.I. J. Biol. Chem. (1989) [Pubmed]
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