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Gene Review

USF1  -  upstream transcription factor 1

Bos taurus

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Disease relevance of USF1

  • Cotransfection experiments showed that the USF1 and USF2a transactivators were able to act through the BLV R region E box [1].

High impact information on USF1


Biological context of USF1

  • By competition and supershift gel shift assays, we demonstrated that the basic helix-loop-helix transcription factors USF1 and USF2 specifically interacted with this R region E box motif [1].

Other interactions of USF1

  • Results revealed that overexpression of USF1 or USF2 caused a marked and significant increase in basal and forskolin-inducible promoter activities (p<0.05), and these effects were dependent on the presence of a consensus E-box cis-element within the promoter fragment [3].

Analytical, diagnostic and therapeutic context of USF1


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