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Gene Review

USF2  -  upstream transcription factor 2, c-fos...

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High impact information on USF2


Biological context of USF2

  • Interestingly, transfections with U2Delta1-220 blocked the forskolin-dependent induction of PGHS-2 mRNA in granulosa cells, whereas transfections with full-length USF2 increased PGHS-2 transcript levels [3].
  • By competition and supershift gel shift assays, we demonstrated that the basic helix-loop-helix transcription factors USF1 and USF2 specifically interacted with this R region E box motif [4].
  • Thus, the ATPA gene is regulated by a multifunctional binding site through which the transcription factors, COUP-TFII/ARP-1 and USF2, bind and exert their antagonistic effects [5].

Physical interactions of USF2


Regulatory relationships of USF2

  • Overexpression of a USF2 truncated mutant lacking the first 220 residues (U2Delta1-220) acted as a dominant negative mutant and blocked endogenous and USF-stimulated PGHS-2 promoter activation [3].

Other interactions of USF2

  • Results revealed that overexpression of USF1 or USF2 caused a marked and significant increase in basal and forskolin-inducible promoter activities (p<0.05), and these effects were dependent on the presence of a consensus E-box cis-element within the promoter fragment [3].

Analytical, diagnostic and therapeutic context of USF2


  1. Role of upstream stimulatory factor phosphorylation in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells. Sayasith, K., Lussier, J.G., Sirois, J. J. Biol. Chem. (2005) [Pubmed]
  2. The delayed activation of the prostaglandin G/H synthase-2 promoter in bovine granulosa cells is associated with down-regulation of truncated upstream stimulatory factor-2. Liu, J., Antaya, M., Boerboom, D., Lussier, J.G., Silversides, D.W., Sirois, J. J. Biol. Chem. (1999) [Pubmed]
  3. Molecular characterization and role of bovine upstream stimulatory factor 1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells. Sayasith, K., Bouchard, N., Sawadogo, M., Lussier, J.G., Sirois, J. J. Biol. Chem. (2004) [Pubmed]
  4. Upstream stimulatory factors binding to an E box motif in the R region of the bovine leukemia virus long terminal repeat stimulates viral gene expression. Calomme, C., Nguyen, T.L., de Launoit, Y., Kiermer, V., Droogmans, L., Burny, A., Van Lint, C. J. Biol. Chem. (2002) [Pubmed]
  5. Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1. Jordan, E.M., Worley, T., Breen, G.A. Biochemistry (2003) [Pubmed]
  6. Transcriptional regulation of the cyclooxygenase-2 gene changes from protein kinase (PK) A- to PKC-dependence after luteinization of granulosa cells. Wu, Y.L., Wiltbank, M.C. Biol. Reprod. (2002) [Pubmed]
  7. Regulation of the nuclear gene that encodes the alpha-subunit of the mitochondrial F0F1-ATP synthase complex. Activation by upstream stimulatory factor 2. Breen, G.A., Jordan, E.M. J. Biol. Chem. (1997) [Pubmed]
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