Disease relevance of TNP1

• The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions [1].

High impact information on TNP1

• The gene order was similar except for two possible minor discrepancies in the Desmin sub-region, suggesting the existence of a porcine micro-region between TNP1 and IL8RB with an unknown origin [2].
• Assignment of the porcine transition protein TNP1 to chromosome 15q24-q25 by fluorescence in situ hybridization (FISH) [3].
• Nucleotide sequences and expression of cDNA clones for boar and bull transition protein 1 and its evolutionary conservation in mammals [4].
• Analysis of transitions at two-fold redundant sites in mammalian genomes. Transition redundant approach-to-equilibrium (TREx) distance metrics [5].
• Transition protein 1 from boar late spermatid nuclei having DNA-melting activity is a dimeric protein [6].

Biological context of TNP1

• The amino acid sequence and phosphorylation sites of a boar transition protein 1 [7].

Anatomical context of TNP1

• In contrast to TNP2 the gene for TNP1 is well conserved among species, indicating a non species-specific function in the chromatin condensation of the spermatid nucleus [8].
• Boar transition protein 1 was extracted with acid from the testes, purified by chromatographies on CM-Sephadex C-25 and Sephadex G-50, and reduced and carboxymethylated [7].

Other interactions of TNP1

• Boar transition protein 1 and 3 were extracted with acid from the late spermatid nuclei, separated from the TP-degrading proteases by ion-exchange chromatography on Fractogel EMD SO3- 650 (M), and further purified by HPLCs on Diol-120 and on Hitachi #3057, respectively [9].

References