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Gene Review

alpha-Est7  -  alpha-Esterase-7

Drosophila melanogaster

Synonyms: Ali, CG1112, DmalphaE7, Dmel\CG1112, EST23, ...
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Disease relevance of alpha-Est7


High impact information on alpha-Est7

  • The results for EST9 and EST23 concur with previous suggestions that the products of the alpha esterase cluster function in digestion and detoxification of xenobiotic esters [2].
  • By peptide mass fingerprinting and in vitro gene expression we have also shown that two of the genes encode the isozymes EST9 (formerly ESTC) and EST23 [2].
  • Phylogenetic analysis suggests that three are homologues of the alpha E7, alpha E8 and alpha E9 genes of the alpha-esterase cluster of D. melanogaster [3].
  • W251L increases dimethyl phosphate hydrolysis similarly, but only 10-fold for the diethyl homolog; unlike G137D however, it also retains ability to hydrolyse carboxylesters in the leaving group of malathion (malathion carboxylesterase, MCE), conferring strong resistance to this compound [4].
  • The enzymes in L. cuprina and D. melanogaster correspond to the naphthyl acetate hydrolyzing E3 and EST23 isozymes of those species [5].

Biological context of alpha-Est7


  1. cDNA cloning, baculovirus-expression and kinetic properties of the esterase, E3, involved in organophosphorus resistance in Lucilia cuprina. Newcomb, R.D., Campbell, P.M., Russell, R.J., Oakeshott, J.G. Insect Biochem. Mol. Biol. (1997) [Pubmed]
  2. Developmental expression and gene/enzyme identifications in the alpha esterase gene cluster of Drosophila melanogaster. Campbell, P.M., de Q Robin, G.C., Court, L.N., Dorrian, S.J., Russell, R.J., Oakeshott, J.G. Insect Mol. Biol. (2003) [Pubmed]
  3. Isolation of alpha cluster esterase genes associated with organophosphate resistance in Lucilia cuprina. Newcomb, R.D., East, P.D., Russell, R.J., Oakeshott, J.G. Insect Mol. Biol. (1996) [Pubmed]
  4. Hydrolysis of organophosphorus insecticides by in vitro modified carboxylesterase E3 from Lucilia cuprina. Heidari, R., Devonshire, A.L., Campbell, B.E., Bell, K.L., Dorrian, S.J., Oakeshott, J.G., Russell, R.J. Insect Biochem. Mol. Biol. (2004) [Pubmed]
  5. Biochemistry of esterases associated with organophosphate resistance in Lucilia cuprina with comparisons to putative orthologues in other Diptera. Campbell, P.M., Trott, J.F., Claudianos, C., Smyth, K.A., Russell, R.J., Oakeshott, J.G. Biochem. Genet. (1997) [Pubmed]
  6. A cluster of esterase genes on chromosome 3R of Drosophila melanogaster includes homologues of esterase genes conferring insecticide resistance in Lucilia cuprina. Spackman, M.E., Oakeshott, J.G., Smyth, K.A., Medveczky, K.M., Russell, R.J. Biochem. Genet. (1994) [Pubmed]
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