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Gene Review

alpha-Est5  -  alpha-Esterase-5

Drosophila melanogaster

Synonyms: CG1089, DmalphaE5, Dmel\CG1089, EST-C, EST9, ...
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High impact information on alpha-Est5

  • Esterase-5 allozyme classes based on electrophoresis in 5% acrylamide gels are therefore highly heterogeneous [1].
  • Molecular evolution of the Sex-Ratio inversion complex in Drosophila pseudoobscura: analysis of the Esterase-5 gene region [2].
  • A 504-bp fragment of noncoding, intergenic DNA from the esterase-5 gene region was amplified and sequenced from 14 Sex-Ratio and 14 Standard X chromosomes of D. pseudoobscura, and from 9 X chromosomes of its two sibling species, Drosophila persimilis and Drosophila miranda [2].
  • A clone of the esterase-5 (Est-5) gene from Drosophila pseudoobscura has been isolated by hybridization to the cloned Est-6 gene of D. melanogaster [3].
  • The extremely close similarity in frequency distributions of the alleles between populations for both the xanthine dehydrogenase and esterase-5 loci, despite differences in allele frequency distribution between loci, strongly emphasizes the importance of migration in influencing genic diversity in these populations [4].

Biological context of alpha-Est5


Anatomical context of alpha-Est5

  • Disc gel electrophoresis of dissected adults of Drosophila pseudoobscura showed that most of the esterase-5 activity was in the head (36%) and thorax (51%), with little activity in the abdomen (13%) [8].

Other interactions of alpha-Est5


Analytical, diagnostic and therapeutic context of alpha-Est5


  1. Allelic heterogeneity within allozymes separated by electrophoresis in Drosophila pseudoobscura. McDowell, R.E., Prakash, S. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  2. Molecular evolution of the Sex-Ratio inversion complex in Drosophila pseudoobscura: analysis of the Esterase-5 gene region. Babcock, C.S., Anderson, W.W. Mol. Biol. Evol. (1996) [Pubmed]
  3. Cloning of the esterase-5 locus from Drosophila pseudoobscura and comparison with its homologue in D. melanogaster. Brady, J.P., Richmond, R.C., Oakeshott, J.G. Mol. Biol. Evol. (1990) [Pubmed]
  4. Nearly identical allelic distributions of xanthine dehydrogenase in two populations of Drosophila pseudoobscura. Keith, T.P., Brooks, L.D., Lewontin, R.C., Martinez-Cruzado, J.C., Rigby, D.L. Mol. Biol. Evol. (1985) [Pubmed]
  5. Molecular population genetics of X-linked genes in Drosophila pseudoobscura. Kovacevic, M., Schaeffer, S.W. Genetics (2000) [Pubmed]
  6. A comparative study of the esterase-5 locus in Drosophila pseudoobscura, D. persimilis and D. miranda. Cobbs, G., Prakash, S. Genetics (1977) [Pubmed]
  7. In vivo phosphorylation of Drosophila melanogaster nuclear lamins during both interphase and mitosis. Rzepecki, R., Fisher, P.A. Cell. Mol. Biol. Lett. (2002) [Pubmed]
  8. Tissue localization of esterase-5 in Drosophila pseudoobscura. Lunday, A.J., Farmer, J.L. Biochem. Genet. (1983) [Pubmed]
  9. Structural comparison of two esterases from Drosophila mojavensis isolated by immunoaffinity chromatography. Pen, J., Van Beeumen, J., Beintema, J.J. Biochem. J. (1986) [Pubmed]
  10. Further evidence for selective differences between isoalleles in Drosophila. Wills, C., Phelps, J., Ferguson, R. Genetics (1975) [Pubmed]
  11. Study of the charge-state model for electrophoretic variation using isoelectric focusing of esterase-5 from Drosophila pseudoobscura. Ramshaw, J.A., Eanes, W.F. Nature (1978) [Pubmed]
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