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Gene Review

CYP2C18  -  cytochrome P450 2C21

Canis lupus familiaris

Synonyms: CYP2C19, CYP2C21, CYPIIC21
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High impact information on CYP2C21


Biological context of CYP2C21


Associations of CYP2C21 with chemical compounds


Analytical, diagnostic and therapeutic context of CYP2C21

  • Reverse transcription-polymerase chain reaction-based restriction enzyme tests for CYP2C21 and 2C41 mRNAs as well as polymerase chain reaction-based tests for genomic DNA were developed [3].


  1. Selective inhibition of dog hepatic CYP2B11 and CYP3A12. Lu, P., Singh, S.B., Carr, B.A., Fang, Y., Xiang, C.D., Rushmore, T.H., Rodrigues, A.D., Shou, M. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  2. Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450. Shou, M., Norcross, R., Sandig, G., Lu, P., Li, Y., Lin, Y., Mei, Q., Rodrigues, A.D., Rushmore, T.H. Drug Metab. Dispos. (2003) [Pubmed]
  3. Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression. Blaisdell, J., Goldstein, J.A., Bai, S.A. Drug Metab. Dispos. (1998) [Pubmed]
  4. In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes. Kuroha, M., Kuze, Y., Shimoda, M., Kokue, E. Am. J. Vet. Res. (2002) [Pubmed]
  5. mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates. Graham, M.J., Bell, A.R., Crewe, H.K., Moorcraft, C.L., Walker, L., Whittaker, E.F., Lennard, M.S. Xenobiotica (2003) [Pubmed]
  6. Evidence for polymorphism in the canine metabolism of the cyclooxygenase 2 inhibitor, celecoxib. Paulson, S.K., Engel, L., Reitz, B., Bolten, S., Burton, E.G., Maziasz, T.J., Yan, B., Schoenhard, G.L. Drug Metab. Dispos. (1999) [Pubmed]
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