The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

CYP1A1  -  cytochrome P450

Canis lupus familiaris

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CYP1A1


High impact information on CYP1A1


Biological context of CYP1A1


Anatomical context of CYP1A1


Associations of CYP1A1 with chemical compounds


Other interactions of CYP1A1


Analytical, diagnostic and therapeutic context of CYP1A1

  • Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection [22].
  • These data indicate qualitative and quantitative sex-dependent differences in the constitutive cytochrome P-450 populations of the dog and suggest that HPLC analysis may be useful for the interpretation of toxicological studies where microsomal enzyme induction is suspected [23].
  • Asp-290 of the phenobarbital-inducible dog liver cytochrome P450 (P450) 2B11 was mutated to nine other amino acid residues by site-directed mutagenesis, and the functional significance of the unique negative charge in P450 2B11 at that position was studied [24].
  • The deduced NH2-terminal 30 amino acids encoded by the dog cDNA are identical to those determined by sequence analysis of purified dog cytochrome P450 PBD-2, and the amino acid composition concurs with that determined for the PBD-2 protein (D. B. Duignan, I. G. Sipes, T. B. Leonard, and J. R. Halpert, 1987, Arch. Biochem. Biophys. 255, 290-303) [25].
  • Cytochrome P-450 isoenzymes were prepared from the solubilized liver microsomes of untreated adult male and female dogs, then separated into groups by high-performance liquid chromatography (HPLC) [23].


  1. Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog. Lambert, C., Halpert, J.R., Rouleau, J., Jutras, L., Leroyer, V., du Souich, P. Drug Metab. Dispos. (1991) [Pubmed]
  2. Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. Nithipatikom, K., DiCamelli, R.F., Kohler, S., Gumina, R.J., Falck, J.R., Campbell, W.B., Gross, G.J. Anal. Biochem. (2001) [Pubmed]
  3. Effects of chloramphenicol on infusion pharmacokinetics of propofol in greyhounds. Mandsager, R.E., Clarke, C.R., Shawley, R.V., Hague, C.M. Am. J. Vet. Res. (1995) [Pubmed]
  4. Inhibition of cytochrome P-450 attenuates hypoxemia of acute lung injury in dogs. Stephenson, A.H., Sprague, R.S., Weintraub, N.L., McMurdo, L., Lonigro, A.J. Am. J. Physiol. (1996) [Pubmed]
  5. Theophylline disposition during acute and chronic hypoxia in the conscious dog. Saunier, C., du Souich, P., Hartemann, D., Sautegeau, A. Res. Commun. Chem. Pathol. Pharmacol. (1987) [Pubmed]
  6. Cytochrome P-450-dependent monooxygenases in olfactory epithelium of dogs: possible role in tumorigenicity. Dahl, A.R., Hadley, W.M., Hahn, F.F., Benson, J.M., McClellan, R.O. Science (1982) [Pubmed]
  7. Organ, species, and compound specificity in the metabolic activation of primary aromatic amines. Poupko, J.M., Radomski, T., Santella, R.M., Radomski, J.L. J. Natl. Cancer Inst. (1983) [Pubmed]
  8. Role of cytochrome P-450 in alveolar hypoxic pulmonary vasoconstriction in dogs. Miller, M.A., Hales, C.A. J. Clin. Invest. (1979) [Pubmed]
  9. The amino-terminal structures that determine topological orientation of cytochrome P-450 in microsomal membrane. Sato, T., Sakaguchi, M., Mihara, K., Omura, T. EMBO J. (1990) [Pubmed]
  10. The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs. Sahi, J., Reyner, E.L., Bauman, J.N., Gueneva-Boucheva, K., Burleigh, J.E., Thomas, V.H. Drug Metab. Dispos. (2002) [Pubmed]
  11. Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs. Uchida, T., Komori, M., Kitada, M., Kamataki, T. Mol. Pharmacol. (1990) [Pubmed]
  12. Transgenic Drosophila carrying mammalian cytochrome P-4501A1: an application to toxicology testing. Komori, M., Kitamura, R., Fukuta, H., Inoue, H., Baba, H., Yoshikawa, K., Kamataki, T. Carcinogenesis (1993) [Pubmed]
  13. Propofol attenuates acetylcholine-induced pulmonary vasorelaxation: role of nitric oxide and endothelium-derived hyperpolarizing factors. Horibe, M., Ogawa, K., Sohn, J.T., Murray, P.A. Anesthesiology (2000) [Pubmed]
  14. Quantitation of cytochrome P450 enzymes (CYP1A1/2, 2B11, 2C21 and 3A12) in dog liver microsomes by enzyme-linked immunosorbent assay. Eguchi, K., Nishibe, Y., Baba, T., Ohno, K. Xenobiotica (1996) [Pubmed]
  15. Nitric oxide-independent dilation of conductance coronary arteries to acetylcholine in conscious dogs. Ming, Z., Parent, R., Lavallée, M. Circ. Res. (1997) [Pubmed]
  16. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Oltman, C.L., Weintraub, N.L., VanRollins, M., Dellsperger, K.C. Circ. Res. (1998) [Pubmed]
  17. In vitro metabolism of polychlorinated biphenyl congeners by beluga whale (Delphinapterus leucas) and pilot whale (Globicephala melas) and relationship to cytochrome P450 expression. White, R.D., Shea, D., Schlezinger, J.J., Hahn, M.E., Stegeman, J.J. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2000) [Pubmed]
  18. Nature of endothelium-derived relaxing factor: are there two relaxing mediators? Rubanyi, G.M., Vanhoutte, P.M. Circ. Res. (1987) [Pubmed]
  19. Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries. Kauser, K., Clark, J.E., Masters, B.S., Ortiz de Montellano, P.R., Ma, Y.H., Harder, D.R., Roman, R.J. Circ. Res. (1991) [Pubmed]
  20. Cytochrome P-450 metabolites but not NO, PGI2, and H2O2 contribute to ACh-induced hyperpolarization of pressurized canine coronary microvessels. Tanaka, M., Kanatsuka, H., Ong, B.H., Tanikawa, T., Uruno, A., Komaru, T., Koshida, R., Shirato, K. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  21. Enhancement of aromatase gene expression in the mediobasal hypothalamus during anestrus in the beagle bitch. Inaba, T., Namura, T., Tani, H., Matsuyama, S., Torii, R., Kawate, N., Tamada, H., Hatoya, S., Kumagai, D., Sugiura, K., Sawada, T. Neurosci. Lett. (2002) [Pubmed]
  22. Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. Nithipatikom, K., Endsley, M.P., Moore, J.M., Isbell, M.A., Falck, J.R., Campbell, W.B., Gross, G.J. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  23. Differences in the constitutive forms of hepatic cytochrome P-450 in male and female adult beagle dogs. Amacher, D.E., Smith, D.J. J. Chromatogr. (1987) [Pubmed]
  24. Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase. Harlow, G.R., Halpert, J.R. Arch. Biochem. Biophys. (1996) [Pubmed]
  25. cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. Graves, P.E., Elhag, G.A., Ciaccio, P.J., Bourque, D.P., Halpert, J.R. Arch. Biochem. Biophys. (1990) [Pubmed]
WikiGenes - Universities