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Gene Review

LARGE  -  like-glycosyltransferase

Gallus gallus

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Disease relevance of LARGE

  • The Large(myd) mouse has a loss-of-function mutation in the putative glycosyltransferase gene Large. Mutations in the human homolog (LARGE) have been described in a form of congenital muscular dystrophy (MDC1D) [1].
  • 1. Large-scale production and purification of complexes between Clostridium botulinum neurotoxin and haemagglutinin have been achieved [2].
  • A similar, but shorter or less basic sequence, was detected in a number of other nuclear proteins, for example, polyoma virus Large T, SV40 VP1 and several histones [3].

High impact information on LARGE

  • A chicken linkage map based on microsatellite markers genotyped on a Japanese Large Game and White Leghorn cross [4].
  • Preservation of hatchery waste by lactic acid fermentation. 2. Large-scale fermentation and feeding trial to evaluate feeding value [5].
  • 5. Large differences were observed between genotypes for plasma-free amino acids [6].
  • Two experiments were conducted with a commercial strain cross of 120 Large White British United Turkeys of America to determine the effect of pantothenic acid egg injections and dietary pantothenic acid on hatchability [7].
  • Two hundred Large White turkey hens were fed diets varying in vitamin D3 supplementation (300, 900, or 2700 IU/kg feed) from day-old to 37 weeks of age [8].

Anatomical context of LARGE


Associations of LARGE with chemical compounds

  • Duplicate groups of Strain-Cross White Leghorn chicks, White Rock Cross broiler chicks, and Large White Turkey poults were fed from 0 to 800 ppm fluoride as NaF for 1 day to 6 weeks [10].
  • 1. Large doses of tungsten, administered to the chick either by injection or by feeding, increased tissue concentrations of tungsten and decreased tissue concentrations of molybdenum and tissue activities of xanthine dehydrogenase [11].


  1. Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies. Grewal, P.K., McLaughlan, J.M., Moore, C.J., Browning, C.A., Hewitt, J.E. Glycobiology (2005) [Pubmed]
  2. Preparation and characterisation of homogeneous neurotoxin type A from Clostridium botulinum. Its inhibitory action on neuronal release of acetylcholine in the absence and presence of beta-bungarotoxin. Tse, C.K., Dolly, J.O., Hambleton, P., Wray, D., Melling, J. Eur. J. Biochem. (1982) [Pubmed]
  3. The nuclear location signal. Smith, A.E., Kalderon, D., Roberts, B.L., Colledge, W.H., Edge, M., Gillett, P., Markham, A., Paucha, E., Richardson, W.D. Proc. R. Soc. Lond., B, Biol. Sci. (1985) [Pubmed]
  4. A chicken linkage map based on microsatellite markers genotyped on a Japanese Large Game and White Leghorn cross. Takahashi, H., Tsudzuki, M., Sasaki, O., Niikura, J., Inoue-Murayama, M., Minezawa, M. Anim. Genet. (2005) [Pubmed]
  5. Preservation of hatchery waste by lactic acid fermentation. 2. Large-scale fermentation and feeding trial to evaluate feeding value. Deshmukh, A.C., Patterson, P.H. Poult. Sci. (1997) [Pubmed]
  6. Comparative utilisation of sulphur-containing amino acids by genetically lean or fat chickens. Leclercq, B., Chagneau, A.M., Cochard, T., Hamzaoui, S., Larbier, M. Br. Poult. Sci. (1993) [Pubmed]
  7. Evaluation of egg injection method of pantothenic acid in turkey eggs and effect of supplemental pantothenic acid on hatchability. Robel, E.J. Poult. Sci. (1993) [Pubmed]
  8. Effect of varying levels of dietary vitamin D3 on turkey hen egg production, fertility and hatchability, embryo mortality and incidence of embryo beak malformations. Stevens, V.I., Blair, R., Salmon, R.E., Stevens, J.P. Poult. Sci. (1984) [Pubmed]
  9. DNA-binding ability and partial purification of the cytoplasmic estrogen receptor from chicken oviduct. Gschwendt, M. Biochim. Biophys. Acta (1980) [Pubmed]
  10. Fluoride tolerance of the young chick and turkey poult. Suttie, J.W., Kolstad, D.L., Sunde, M.L. Poult. Sci. (1984) [Pubmed]
  11. The influence of tungsten on the molybdenum status of poultry. Nell, J.A., Annison, E.F., Balnave, D. Br. Poult. Sci. (1980) [Pubmed]
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