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Gene Review

EndoA  -  Endophilin A

Drosophila melanogaster

Synonyms: CG14296, D-endo, D-endoA, Dendo-A, Dmel\CG14296, ...
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High impact information on endoA


Biological context of endoA


Anatomical context of endoA

  • Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating [7].
  • Moreover, synj; endo double mutant synaptic terminals exhibit properties that are very similar to terminals of each single mutant, and overexpression of Endophilin can partially rescue the functional defects in partial loss-of-function synj mutants [7].
  • Detailed ultrastructural analysis of endo null mutant photoreceptor synapses fails to reveal a defect at early stages of vesicle reformation but, instead, reveals an accumulation of clusters of electron-dense, apparently nonfunctional, late endocytotic vesicles [4].
  • Decreased endophilin activity results in alterations in the neuromuscular junction structure and physiology [5].

Associations of endoA with chemical compounds


Other interactions of endoA


Analytical, diagnostic and therapeutic context of endoA


  1. A slowed classical pathway rather than kiss-and-run mediates endocytosis at synapses lacking synaptojanin and endophilin. Dickman, D.K., Horne, J.A., Meinertzhagen, I.A., Schwarz, T.L. Cell (2005) [Pubmed]
  2. Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Verstreken, P., Kjaerulff, O., Lloyd, T.E., Atkinson, R., Zhou, Y., Meinertzhagen, I.A., Bellen, H.J. Cell (2002) [Pubmed]
  3. Postfusional control of quantal current shape. Pawlu, C., DiAntonio, A., Heckmann, M. Neuron (2004) [Pubmed]
  4. Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals. Fabian-Fine, R., Verstreken, P., Hiesinger, P.R., Horne, J.A., Kostyleva, R., Zhou, Y., Bellen, H.J., Meinertzhagen, I.A. J. Neurosci. (2003) [Pubmed]
  5. Endophilin is critically required for synapse formation and function in Drosophila melanogaster. Rikhy, R., Kumar, V., Mittal, R., Krishnan, K.S. J. Neurosci. (2002) [Pubmed]
  6. Identification and characterization of a sphingolipid delta 4-desaturase family. Ternes, P., Franke, S., Zähringer, U., Sperling, P., Heinz, E. J. Biol. Chem. (2002) [Pubmed]
  7. Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Verstreken, P., Koh, T.W., Schulze, K.L., Zhai, R.G., Hiesinger, P.R., Zhou, Y., Mehta, S.Q., Cao, Y., Roos, J., Bellen, H.J. Neuron (2003) [Pubmed]
  8. Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction. Guichet, A., Wucherpfennig, T., Dudu, V., Etter, S., Wilsch-Bräuniger, M., Hellwig, A., González-Gaitán, M., Huttner, W.B., Schmidt, A.A. EMBO J. (2002) [Pubmed]
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