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Gene Review

GLS  -  glutaminase

Gallus gallus

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Disease relevance of RCJMB04_23e15


High impact information on RCJMB04_23e15

  • The localization of a glutaminase activity within avian liver mitochondria plus the absence of an active mitochondrial glutamine transaminase is consistent with the differential effects of the transaminase and glutamate dehydrogenase inhibitors [2].
  • In contrast to neurons, there was no significant increase of glutaminase activity in glial cells before the fifteenth day of culture [3].
  • Glutaminase activity was determined in pure cultures of neurons, glial cells and in mixed cultures obtained from chick embryo brain [3].
  • The specific activity of brain glutaminase increased between the twelfth and sixteenth day of embryogenesis [3].
  • METHODS: In the course of an acute TOCP-induced toxic neuropathy in hens the activity of following enzymes was analysed: asparaginase, glutaminase, glutamat-dehydrogenase, AMP and adenosine deaminases and 5'nucleotidase; ALT (SGPT), AST (SGOT) and proteins levels were estimated [4].

Anatomical context of RCJMB04_23e15


Regulatory relationships of RCJMB04_23e15

  • However, chicken breast muscle expresses high glutaminase activity and here we report that chicken breast muscle also expresses low glutamine synthetase activity (0.07+/-0.01 U/g) when compared to leg muscle (0.50+/-0.04 U/g) [6].


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