Disease relevance of RCJMB04_23e15

• Glutaminase I was not found in the liver, but hepatic glutamine synthetase rose markedly during acidosis [1].

High impact information on RCJMB04_23e15

• The localization of a glutaminase activity within avian liver mitochondria plus the absence of an active mitochondrial glutamine transaminase is consistent with the differential effects of the transaminase and glutamate dehydrogenase inhibitors [2].
• In contrast to neurons, there was no significant increase of glutaminase activity in glial cells before the fifteenth day of culture [3].
• Glutaminase activity was determined in pure cultures of neurons, glial cells and in mixed cultures obtained from chick embryo brain [3].
• The specific activity of brain glutaminase increased between the twelfth and sixteenth day of embryogenesis [3].
• METHODS: In the course of an acute TOCP-induced toxic neuropathy in hens the activity of following enzymes was analysed: asparaginase, glutaminase, glutamat-dehydrogenase, AMP and adenosine deaminases and 5'nucleotidase; ALT (SGPT), AST (SGOT) and proteins levels were estimated [4].

Anatomical context of RCJMB04_23e15

• 1. Glutaminase activity was evaluated in the chick cerebral hemispheres, optic lobes and cerebellum between the 1st and 30th day of postnatal growth [5].
• Glutaminase activity in the chick central nervous system during postnatal growth [5].
• Glutamine metabolism in uricotelic species: variation in skeletal muscle glutamine synthetase, glutaminase, glutamine levels and rates of protein synthesis [6].

Regulatory relationships of RCJMB04_23e15

• However, chicken breast muscle expresses high glutaminase activity and here we report that chicken breast muscle also expresses low glutamine synthetase activity (0.07+/-0.01 U/g) when compared to leg muscle (0.50+/-0.04 U/g) [6].

References