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Gene Review

FDPS  -  farnesyl diphosphate synthase (farnesyl...

Gallus gallus

Synonyms: (2E, FPS
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Disease relevance of FDPS

  • Antibodies to chicken FPS cross-react with both guayule isoforms expressed in E. coli and recognize a low abundance M(r) 39,000 protein in rubber particles purified from guayule stembark [1].

High impact information on FDPS


Analytical, diagnostic and therapeutic context of FDPS

  • Farnesyl pyrophosphate synthetase (EC from chicken liver, pig liver, and yeast has been purified to homogeneity in a single chromatographic step by affinity chromatography [4].


  1. Cloning, characterization, and heterologous expression of cDNAs for farnesyl diphosphate synthase from the guayule rubber plant reveals that this prenyltransferase occurs in rubber particles. Pan, Z., Herickhoff, L., Backhaus, R.A. Arch. Biochem. Biophys. (1996) [Pubmed]
  2. Regulation of product chain length by isoprenyl diphosphate synthases. Tarshis, L.C., Proteau, P.J., Kellogg, B.A., Sacchettini, J.C., Poulter, C.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution. Tarshis, L.C., Yan, M., Poulter, C.D., Sacchettini, J.C. Biochemistry (1994) [Pubmed]
  4. An affinity column for the purification of prenyltransferases. Bartlett, D.L., King, C.H., Poulter, C.D. Anal. Biochem. (1985) [Pubmed]
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