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Gene Review:

FDPS - farnesyl diphosphate synthase (farnesyl...

Gallus gallus

Synonyms: (2E, FPS

Tarshis, L.C. et al., Tarshis, L.C. et al., Pan, Z. et al., Bartlett, D.L. et al.

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Disease relevance of FDPS

Antibodies to chicken FPS cross-react with both guayule isoforms expressed in E. coli and recognize a low abundance M(r) 39,000 protein in rubber particles purified from guayule stembark [1].

High impact information on FDPS

This hypothesis was supported by site-directed mutagenesis to transform wild-type avian farnesyl diphosphate synthase (FPS) into synthases capable of producing geranylgeranyl diphosphate (F112A), geranylfarnesyl (C25) diphosphate (F113S), and longer chain prenyl diphosphates (F112A/F113S) [2].
A model was constructed to show how the growth of a long chain prenyl product may proceed by creation of a hydrophobic passageway from the FPS active site to the outside surface of the enzyme [2].
The synthesis of farnesyl diphosphate (FPP), a key intermediate in the isoprenoid biosynthetic pathway required for the synthesis of cholesterol and in the formation of prenylated proteins, is catalyzed by the enzyme farnesyl diphosphate synthase (FPS) [3].

Analytical, diagnostic and therapeutic context of FDPS

Farnesyl pyrophosphate synthetase (EC 2.5.1.1) from chicken liver, pig liver, and yeast has been purified to homogeneity in a single chromatographic step by affinity chromatography [4].

References

Cloning, characterization, and heterologous expression of cDNAs for farnesyl diphosphate synthase from the guayule rubber plant reveals that this prenyltransferase occurs in rubber particles. Pan, Z., Herickhoff, L., Backhaus, R.A. Arch. Biochem. Biophys. (1996) [Pubmed]
Regulation of product chain length by isoprenyl diphosphate synthases. Tarshis, L.C., Proteau, P.J., Kellogg, B.A., Sacchettini, J.C., Poulter, C.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution. Tarshis, L.C., Yan, M., Poulter, C.D., Sacchettini, J.C. Biochemistry (1994) [Pubmed]
An affinity column for the purification of prenyltransferases. Bartlett, D.L., King, C.H., Poulter, C.D. Anal. Biochem. (1985) [Pubmed]

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AgaP_AGAP007104	Anopheles gambiae str. PEST
FPS2	Arabidopsis thaliana
FPS1	Arabidopsis thaliana
AGOS_AEL122W	Ashbya gossypii ATCC 10895
FDPS	Bos taurus
FDPS	Canis lupus familiaris
fdps	Danio rerio
Fpps	Drosophila melanogaster
FDPS	Homo sapiens
KLLA0A06732g	Kluyveromyces lactis NRRL Y-1140
MGG_08649	Magnaporthe oryzae 70-15
Fdps	Mus musculus
NCU01175	Neurospora crassa OR74A
Os05g0543400	Oryza sativa Japonica Group
Os01g0703400	Oryza sativa Japonica Group
FDPS	Pan troglodytes
Fdps	Rattus norvegicus
ERG20	Saccharomyces cerevisiae S288c
fps1	Schizosaccharomyces pombe 972h-
fdps	Xenopus (Silurana) tropicalis

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