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Gene Review

bap  -  bagpipe

Drosophila melanogaster

Synonyms: BAP, Bap, CG7902, Dmel\CG7902, Homeobox protein NK-3, ...
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High impact information on bap

  • We focus on the regulation of two mesodermal genes: bagpipe (bap), which defines the anlagen of the visceral musculature of the midgut, and serpent (srp), which marks the anlagen of the fat body [1].
  • Here, we describe two homeo box genes, tinman (tin) and bagpipe (bap), which spatially subdivide the mesoderm and determine cell fates in the dorsal mesoderm [2].
  • In embryos mutant for bap, visceral mesoderm formation is strongly disrupted [2].
  • The mouse Bapx1 gene is homologous to the Drosophila homeobox containing bagpipe (bap) gene [3].
  • Our present study addresses how positive Dpp signals and antagonistic Wg inputs are integrated at the enhancer level of bagpipe (bap), a NK homeobox gene that serves as an early regulator of visceral mesoderm development [4].

Biological context of bap

  • In addition, we show that binding sites for yet unknown repressors are essential to prevent the induction of the bap enhancer by Dpp in the dorsal ectoderm [4].
  • The haplotype structure of bap is more complex: about half of the sequences are identical (or virtually so), while the rest are fairly heterogeneous [5].
  • Recombination rate and gene conversion are also higher for bap than for tin [5].
  • There is strong linkage disequilibrium, with the highest values in the introns of both genes and exon II of bap [5].
  • Mtn transcription is not altered in homozygous mutants of four genes (lab, wg, dpp, bap) known to be involved in midgut morphogenesis [6].

Anatomical context of bap

  • An evolutionarily conserved vertebrate homologue of the Drosophila NK-3 homeodomain gene bagpipe, Nkx3-1, is expressed in vascular and visceral mesoderm-derived muscle tissues and may influence smooth muscle cell differentiation [7].

Physical interactions of bap

  • We show that an evolutionarily conserved bap enhancer element requires combinatorial binding sites for Tin and Dpp-activated Smad proteins for its activity [4].


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