Gene Review:
Nkx3-2 - NK3 homeobox 2
Mus musculus
Synonyms:
Bagpipe homeobox protein homolog 1, Bapx1, Homeobox protein NK-3 homolog B, Homeobox protein Nkx-3.2, NKX3.2, ...
- Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation. Provot, S., Kempf, H., Murtaugh, L.C., Chung, U.I., Kim, D.W., Chyung, J., Kronenberg, H.M., Lassar, A.B. Development (2006)
- Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice. Asayesh, A., Sharpe, J., Watson, R.P., Hecksher-Sørensen, J., Hastie, N.D., Hill, R.E., Ahlgren, U. Genes Dev. (2006)
- The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Lu, J., Chang, P., Richardson, J.A., Gan, L., Weiler, H., Olson, E.N. Proc. Natl. Acad. Sci. U.S.A. (2000)
- The mouse bagpipe gene controls development of axial skeleton, skull, and spleen. Lettice, L.A., Purdie, L.A., Carlson, G.J., Kilanowski, F., Dorin, J., Hill, R.E. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. Kim, D.W., Lassar, A.B. Mol. Cell. Biol. (2003)
- Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution. Tucker, A.S., Watson, R.P., Lettice, L.A., Yamada, G., Hill, R.E. Development (2004)
- The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Tribioli, C., Lufkin, T. Development (1999)
- Transcription factors Nkx3.1 and Nkx3.2 (Bapx1) play an overlapping role in sclerotomal development of the mouse. Herbrand, H., Pabst, O., Hill, R., Arnold, H.H. Mech. Dev. (2002)
- Characterization of Nkx3.2 DNA binding specificity and its requirement for somitic chondrogenesis. Kim, D.W., Kempf, H., Chen, R.E., Lassar, A.B. J. Biol. Chem. (2003)
- Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome. Rodrigo, I., Hill, R.E., Balling, R., Münsterberg, A., Imai, K. Development (2003)
- A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Brendolan, A., Ferretti, E., Salsi, V., Moses, K., Quaggin, S., Blasi, F., Cleary, M.L., Selleri, L. Development (2005)
- Bapx1 homeobox gene gain-of-function mice show preaxial polydactyly and activated Shh signaling in the developing limb. Tribioli, C., Lufkin, T. Dev. Dyn. (2006)
- Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation. Akazawa, H., Komuro, I., Sugitani, Y., Yazaki, Y., Nagai, R., Noda, T. Genes Cells (2000)