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Gene Review

p38a  -  p38a MAP kinase

Drosophila melanogaster

Synonyms: CG5475, D-MPK2, D-P38a, D-p38, D-p38 MAPK, ...
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High impact information on Mpk2

  • The fruit fly, Drosophila melanogaster, has two p38 genes, D-p38a and D-p38b [1].
  • However, flies lacking D-p38a are susceptible to some environmental stresses, including heat shock, oxidative stress and starvation [2].
  • Analysis of an F2 intercross population derived from a parental cross between two Ae. aegypti strains (Hamburg and Moyo-In-Dry) allowed us to map Ddc to a locus on linkage group 2 [3].
  • Group 2 consists of species B and C, which show prominent landmarks of pericentric heterochromatin in all autosomes and in the X chromosome [4].
  • Mitogen-activated protein kinases such as Erk1 and Erk2 serve as a paradigm for a growing family of proline-directed protein kinases that mediate entry, progression and exit from the cell cycle in diverse eukaryotic cells [5].


  1. p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis. Adachi-Yamada, T., Nakamura, M., Irie, K., Tomoyasu, Y., Sano, Y., Mori, E., Goto, S., Ueno, N., Nishida, Y., Matsumoto, K. Mol. Cell. Biol. (1999) [Pubmed]
  2. A Drosophila p38 orthologue is required for environmental stress responses. Craig, C.R., Fink, J.L., Yagi, Y., Ip, Y.T., Cagan, R.L. EMBO Rep. (2004) [Pubmed]
  3. Mosquito dopa decarboxylase cDNA characterization and blood-meal-induced ovarian expression. Ferdig, M.T., Li, J., Severson, D.W., Christensen, B.M. Insect Mol. Biol. (1996) [Pubmed]
  4. Metaphase karyotypes of fruit flies of Thailand. I. Five sibling species of the Bactrocera dorsalis complex. Baimai, V., Trinachartvanit, W., Tigvattananont, S., Grote, P.J., Poramarcom, R., Kijchalao, U. Genome (1995) [Pubmed]
  5. MAP kinase-dependent pathways in cell cycle control. Pelech, S.L., Charest, D.L. Progress in cell cycle research. (1995) [Pubmed]
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