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Gene Review

pmk-1  -  Protein PMK-1

Caenorhabditis elegans

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Disease relevance of pmk-1

  • Genetic epistasis analysis indicates that OSR-1 regulates survival under osmotic stress via CaMKII and a conserved p38 MAP kinase signaling cascade and regulates osmotic avoidance and resistance to acute dehydration likely by distinct mechanisms [1].

High impact information on pmk-1

  • Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development [2].
  • We report that RPM-1 negatively regulates a p38 MAP kinase pathway composed of the dual leucine zipper-bearing MAPKKK DLK-1, the MAPKK MKK-4, and the p38 MAP kinase PMK-3 [2].
  • Conserved signal transduction components are required for pathogen resistance, including a Toll/IL-1 receptor domain adaptor protein that functions upstream of a conserved p38 MAP kinase pathway [3].
  • Enhanced susceptibility to S. aureus killing was observed with loss-of-function mutations in the C. elegans genes esp-2/sek-1 and esp-8/nsy-1, which encode components of a conserved p38 MAP kinase signaling pathway involved in nematode defense against multiple pathogens [4].
  • In keeping with this concept, experiments aimed at identifying host innate immunity genes have also implicated pathways that have been suggested to play a role in plants and animals, such as the p38 MAP kinase pathway [5].

Biological context of pmk-1


  1. Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments. Solomon, A., Bandhakavi, S., Jabbar, S., Shah, R., Beitel, G.J., Morimoto, R.I. Genetics (2004) [Pubmed]
  2. Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Nakata, K., Abrams, B., Grill, B., Goncharov, A., Huang, X., Chisholm, A.D., Jin, Y. Cell (2005) [Pubmed]
  3. Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans. Kim, D.H., Ausubel, F.M. Curr. Opin. Immunol. (2005) [Pubmed]
  4. Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Sifri, C.D., Begun, J., Ausubel, F.M., Calderwood, S.B. Infect. Immun. (2003) [Pubmed]
  5. Characterization of mediators of microbial virulence and innate immunity using the Caenorhabditis elegans host-pathogen model. Alegado, R.A., Campbell, M.C., Chen, W.C., Slutz, S.S., Tan, M.W. Cell. Microbiol. (2003) [Pubmed]
  6. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Kim, D.H., Feinbaum, R., Alloing, G., Emerson, F.E., Garsin, D.A., Inoue, H., Tanaka-Hino, M., Hisamoto, N., Matsumoto, K., Tan, M.W., Ausubel, F.M. Science (2002) [Pubmed]
  7. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Nicholas, H.R., Hodgkin, J. Mol. Immunol. (2004) [Pubmed]
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