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Gene Review: 

mapk14a  -  mitogen-activated protein kinase 14a

Danio rerio

Synonyms: MAP kinase 14A, MAP kinase p38a, MAPK 14A, MAPK14, Mitogen-activated protein kinase 14A, ...
 
 
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High impact information on mapk14a

  • The area affected by the DN-p38 expression did not correlate with the initial cleavage plane, but coincided with the side where dharma/bozozok, a dorsal-specific zygotic gene, was expressed (Yamanaka et al. 1998) [1].
  • When a dominant negative (DN) form of p38 was uniformly expressed, blastomere cleavage was impaired on one side of the blastodisc, resulting in the formation of blastomeres with a large mass of cytoplasm and an enlarged nucleus on the affected side [1].
  • Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase [2].
  • Erk2,3 and p38a were expressed at a constant level throughout zebrafish embryogenesis, whereas erk1,4,5,6,7 and p38b showed specific temporal expression patterns [3].

References

  1. Asymmetric p38 activation in zebrafish: its possible role in symmetric and synchronous cleavage. Fujii, R., Yamashita, S., Hibi, M., Hirano, T. J. Cell Biol. (2000) [Pubmed]
  2. Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. Mikkola, I., Bruun, J.A., Bjorkoy, G., Holm, T., Johansen, T. J. Biol. Chem. (1999) [Pubmed]
  3. Characterization and expression patterns of the MAPK family in zebrafish. Krens, S.F., He, S., Spaink, H.P., Snaar-Jagalska, B.E. Gene Expr. Patterns (2006) [Pubmed]
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