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Gene Review

MPK3  -  mitogen-activated protein kinase 3

Arabidopsis thaliana

Synonyms: ATMAPK3, ATMPK3, T6D9.4
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High impact information on ATMPK3


Biological context of ATMPK3

  • The MPK6-RNAi genotype also displayed a more intense and prolonged activation of MPK3 compared to that of WT plants [4].

Other interactions of ATMPK3

  • Whereas mpk3 and mpk6 knock out plants showed no defects in development or changes in redox control genes, mpk4 null mutant shared several phenotypic and transcript profile features with mekk1 plants [5].

Analytical, diagnostic and therapeutic context of ATMPK3

  • OXI1 is required for full activation of the mitogen-activated protein kinases (MAPKs) MPK3 and MPK6 after treatment with AOS or elicitor and is necessary for at least two very different AOS-mediated processes: basal resistance to Peronospora parasitica infection, and root hair growth [6].


  1. NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants. Moon, H., Lee, B., Choi, G., Shin, D., Prasad, D.T., Lee, O., Kwak, S.S., Kim, D.H., Nam, J., Bahk, J., Hong, J.C., Lee, S.Y., Cho, M.J., Lim, C.O., Yun, D.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. High humidity suppresses ssi4-mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defense gene expression. Zhou, F., Menke, F.L., Yoshioka, K., Moder, W., Shirano, Y., Klessig, D.F. Plant J. (2004) [Pubmed]
  3. Characterization of early, chitin-induced gene expression in Arabidopsis. Zhang, B., Ramonell, K., Somerville, S., Stacey, G. Mol. Plant Microbe Interact. (2002) [Pubmed]
  4. RNA interference-based (RNAi) suppression of AtMPK6, an Arabidopsis mitogen-activated protein kinase, results in hypersensitivity to ozone and misregulation of AtMPK3. Miles, G.P., Samuel, M.A., Zhang, Y., Ellis, B.E. Environ. Pollut. (2005) [Pubmed]
  5. A Mitogen-activated Protein Kinase Kinase Kinase Mediates Reactive Oxygen Species Homeostasis in Arabidopsis. Nakagami, H., Soukupov??, H., Schikora, A., Z??rsky, V., Hirt, H. J. Biol. Chem. (2006) [Pubmed]
  6. OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis. Rentel, M.C., Lecourieux, D., Ouaked, F., Usher, S.L., Petersen, L., Okamoto, H., Knight, H., Peck, S.C., Grierson, C.S., Hirt, H., Knight, M.R. Nature (2004) [Pubmed]
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