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Gene Review

OXTR  -  oxytocin receptor

Gallus gallus

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High impact information on OXTR

  • Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium [1].
  • The highly specific binding of hMafF to the US-2 motif in the human OTR gene, together with its pattern of expression, supports a role for hMafF in OTR gene upregulation at term [1].
  • The US-2 DNA-binding element (ggaatgattactcagctaga) in the promoter of the human oxytocin receptor (OTR) gene has been shown to bind specifically nuclear proteins from human myometrium at parturition [1].
  • To elucidate the molecular mechanisms involved in OTR gene upregulation at term, the US-2 element was used in a yeast one-hybrid system to screen a cDNA library derived from term human myometrium [1].
  • The expression of the OTR within the mammalian uterus is regulated during gestation with a peak at the day of delivery [2].

Biological context of OXTR

  • The oxytocin (OT) -oxytocin receptor (OTR) system plays a key role in many aspects of mammalian reproduction as well as several other physiological processes such as bond pairing and cardiovascular homeostasis [2].

Anatomical context of OXTR

  • This review summarizes the current knowledge of the complex regulation of OTR transcription in the myometrium and the intracellular signaling mechanisms through which OT mediates its potent stimulatory effects [2].
  • The activated OTR increases contraction frequency and increases force by sensitizing the contractile apparatus of the myocytes to calcium [2].

Analytical, diagnostic and therapeutic context of OXTR


  1. Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium. Kimura, T., Ivell, R., Rust, W., Mizumoto, Y., Ogita, K., Kusui, C., Matsumura, Y., Azuma, C., Murata, Y. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  2. Regulation of oxytocin receptors and oxytocin receptor signaling. Blanks, A.M., Shmygol, A., Thornton, S. Semin. Reprod. Med. (2007) [Pubmed]
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