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Gene Review

OXTR  -  oxytocin receptor

Bos taurus

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Disease relevance of OXTR


High impact information on OXTR

  • We do not presently understand the mechanisms of OTR up-regulation in human myometrium in vivo, but the present studies might lead to the description of mRNA-stabilizing factors whose activity can be quantified in tissue samples during pregnancy to elucidate the process of OTR up-regulation [2].
  • Oxytocin receptor (OTR) expression in human myometrium increases over 150-fold from the beginning of pregnancy to the end [2].
  • In the present studies, we examined potential mechanisms of OTR up-regulation, using myometrial cells in primary culture from women in late gestation [2].
  • Likewise, inhibition of G(i/o) signaling by elevation of intracellular cAMP or inhibition of phosphoinositol 3-phosphate kinase blocked FBS effects on OTR mRNA stability [2].
  • [3H]OT binding and specificity, localization of immunoreactive (ir) OTR, OTR messenger RNA, and OT-induced release of PGF2alpha were determined [3].

Biological context of OXTR


Anatomical context of OXTR


Associations of OXTR with chemical compounds

  • These data show that E2 can stimulate PGF2 alpha secretion by increasing OTR expression in bovine endometrial cells in vitro, but only after exposure to P4 [8].
  • The molar ratio of estrone and estradiol-17 beta to progesterone rose from less than 0.01 to 4.4 during labor, and was correlated with oxytocin receptor concentrations in endometrium (r = 0.5160, p < 0.001), but not those in myometrium (r = 0.0122) [11].
  • When the granulosa cells obtained from small follicles were cultured in Dulbecco's Modified Eagle's Medium and Ham's F-12 medium (1:1 [v:v]) with 10% calf serum up to 72 h, as the period of culture was prolonged, the concentration of OT receptor decreased with increases of progesterone and OT release in the medium [12].
  • OT significantly increased PGF2alpha and PGE2 secretion at all time points (p < 0.01), while rbIFN-tau inhibited the OT-induced PG production and reduced OT receptor binding in a time-dependent manner [13].
  • The objective of the present study was to determine, whether this effect of mifepristone was due to changes in prostaglandin synthesis and/or OTR [14].

Physical interactions of OXTR


Regulatory relationships of OXTR


Other interactions of OXTR


Analytical, diagnostic and therapeutic context of OXTR


  1. Atosiban, an oxytocin receptor blocking agent: pharmacokinetics and inhibition of milk ejection in dairy cows. Wellnitz, O., Bruckmaier, R.M., Albrecht, C., Blum, J.W. J. Dairy Res. (1999) [Pubmed]
  2. Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. Jeng, Y.J., Soloff, S.L., Anderson, G.D., Soloff, M.S. Endocrinology (2003) [Pubmed]
  3. Ontogeny of oxytocin receptors and oxytocin-induced stimulation of prostaglandin synthesis in prepubertal heifers. Fuchs, A.R., Drolet, P., Fortier, M.A., Balvers, M., Fields, M.J. Endocrinology (1998) [Pubmed]
  4. Transcriptional regulation of the bovine oxytocin receptor gene. Telgmann, R., Bathgate, R.A., Jaeger, S., Tillmann, G., Ivell, R. Biol. Reprod. (2003) [Pubmed]
  5. Structure and expression of the bovine oxytocin receptor gene. Bathgate, R., Rust, W., Balvers, M., Hartung, S., Morley, S., Ivell, R. DNA Cell Biol. (1995) [Pubmed]
  6. Oxytocin receptors in bovine cervix: distribution and gene expression during the estrous cycle. Fuchs, A.R., Ivell, R., Fields, P.A., Chang, S.M., Fields, M.J. Biol. Reprod. (1996) [Pubmed]
  7. Changes in uterine oxytocin receptor concentrations throughout the estrous cycle of the cow. Soloff, M.S., Fields, M.J. Biol. Reprod. (1989) [Pubmed]
  8. Prolonged progesterone treatment of endometrial epithelial cells modifies the effect of estradiol on their sensitivity to oxytocin. Kombé, A., Sirois, J., Goff, A.K. Steroids (2003) [Pubmed]
  9. The concentrations of catecholamines and oxytocin receptors in the oviduct and its contractile activity in cows during the estrous cycle. Kotwica, G., Kurowicka, B., Franczak, A., Grzegorzewski, W., Wrobel, M., Mlynarczuk, J., Kotwica, J. Theriogenology (2003) [Pubmed]
  10. Interferon tau: a novel pregnancy recognition signal. Bazer, F.W., Spencer, T.E., Ott, T.L. Am. J. Reprod. Immunol. (1997) [Pubmed]
  11. Oxytocin and bovine parturition: a steep rise in endometrial oxytocin receptors precedes onset of labor. Fuchs, A.R., Helmer, H., Behrens, O., Liu, H.C., Antonian, L., Chang, S.M., Fields, M.J. Biol. Reprod. (1992) [Pubmed]
  12. Functional oxytocin receptors in bovine granulosa cells. Okuda, K., Uenoyama, Y., Fujita, Y., Iga, K., Sakamoto, K., Kimura, T. Biol. Reprod. (1997) [Pubmed]
  13. Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. Xiao, C.W., Murphy, B.D., Sirois, J., Goff, A.K. Biol. Reprod. (1999) [Pubmed]
  14. Inhibition of prostaglandin F2alpha synthesis and oxytocin receptor by progesterone antagonists in bovine endometrial cells in vitro. Goff, A.K., Jamshidi, A.A., Kombé, A. Steroids (2006) [Pubmed]
  15. Changes in oxytocin receptor in bovine preovulatory follicles between the gonadotropin surge and ovulation. Jo, M., Fortune, J.E. Mol. Cell. Endocrinol. (2003) [Pubmed]
  16. Functional expression of the oxytocin receptor in Xenopus laevis oocytes primed with mRNA from bovine endometrium. Morley, S.D., Meyerhof, W., Schwarz, J., Richter, D. J. Mol. Endocrinol. (1988) [Pubmed]
  17. Expression of the antiviral protein Mx in peripheral blood mononuclear cells of pregnant and bred, non-pregnant ewes. Yankey, S.J., Hicks, B.A., Carnahan, K.G., Assiri, A.M., Sinor, S.J., Kodali, K., Stellflug, J.N., Stellflug, J.N., Ott, T.L. J. Endocrinol. (2001) [Pubmed]
  18. Oxytocin induces prostaglandin F2 alpha release in pregnant cows: influence of gestational age and oxytocin receptor concentrations. Fuchs, A.R., Rollyson, M.K., Meyer, M., Fields, M.J., Minix, J.M., Randel, R.D. Biol. Reprod. (1996) [Pubmed]
  19. Oxytocin and oxytocin receptor gene expression in the reproductive tract of the pregnant cow: rescue of luteal oxytocin production at term. Ivell, R., Rust, W., Einspanier, A., Hartung, S., Fields, M., Fuchs, A.R. Biol. Reprod. (1995) [Pubmed]
  20. Ovine conceptus secretory proteins and bovine recombinant interferon alpha (1)-1 decrease endometrial oxytocin receptor concentrations in cyclic and progesterone-treated ovariectomized ewes. Vallet, J.L., Lamming, G.E. J. Endocrinol. (1991) [Pubmed]
  21. Expression of oxytocin, oestrogen and progesterone receptors in uterine biopsy samples throughout the oestrous cycle and early pregnancy in cows. Robinson, R.S., Mann, G.E., Lamming, G.E., Wathes, D.C. Reproduction (2001) [Pubmed]
  22. Evidence for oxytocin receptors in cultured bovine luteal cells. Okuda, K., Miyamoto, A., Sauerwein, H., Schweigert, F.J., Schams, D. Biol. Reprod. (1992) [Pubmed]
  23. Local action of trophoblast interferons in suppression of the development of oxytocin and oestradiol receptors in ovine endometrium. Lamming, G.E., Wathes, D.C., Flint, A.P., Payne, J.H., Stevenson, K.R., Vallet, J.L. J. Reprod. Fertil. (1995) [Pubmed]
  24. The effect of pregnancy on the expression of uterine oxytocin, oestrogen and progesterone receptors during early pregnancy in the cow. Robinson, R.S., Mann, G.E., Lamming, G.E., Wathes, D.C. J. Endocrinol. (1999) [Pubmed]
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