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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hex-t2  -  CG32849 gene product from transcript...

Drosophila melanogaster

Synonyms: CG32849, CG5443, Dmel\CG32849, HK, Hex, ...
 
 
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Disease relevance of Hex-t2

 

High impact information on Hex-t2

  • In D. melanogaster latitudinal clines are seen for amino acid polymorphisms at the Hex-C and Hex-t2 loci [2].
  • The analog was also found to be a substrate for all of the enzymes tested, including creatine kinase, pyruvate kinase, hexokinase, and myosin, with values of Km and Vmax that were within a factor of 10 of those for ATP [3].
  • A portion of the 5'-flanking region of the female-specific hexamerin gene, Hex-1.2, from the mosquito Ochlerotatus atropalpus was used to drive expression of the luciferase reporter gene in Drosophila melanogaster [1].
 

Biological context of Hex-t2

  • The proximal 0.7 kb of 5'-flanking DNA were sufficient to partially repress reporter gene activity in males and to drive tissue- and stage-specific expression comparable with that of the endogenous O. atropalpus Hex-1.2 gene [1].

References

  1. Sex-, stage- and tissue-specific regulation by a mosquito hexamerin promoter. Jinwal, U.K., Zakharkin, S.O., Litvinova, O.V., Jain, S., Benes, H. Insect Mol. Biol. (2006) [Pubmed]
  2. Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba. Duvernell, D.D., Eanes, W.F. Genetics (2000) [Pubmed]
  3. A novel adenosine triphosphate analog with a heavy atom to target the nucleotide binding site of proteins. Naber, N., Matuska, M., Sablin, E.P., Pate, E., Cooke, R. Protein Sci. (1995) [Pubmed]
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