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Gene Review

PyK  -  Pyruvate kinase

Drosophila melanogaster

Synonyms: CG7070, Dmel\CG7070, PYK, Pyk, l(3)r[Q178]
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Disease relevance of PyK


High impact information on PyK


Biological context of PyK


Anatomical context of PyK

  • Changes in the activity of 3 enzymes--lactate dehydrogenase (LDH), soluble malate dehydrogenase (sMDH), and pyruvate kinase (PK)--in homogenates of larval salivary glands of Drosophila melanogaster were studied before and after the induction of heat sensitive puffs with trinactin [8].

Analytical, diagnostic and therapeutic context of PyK

  • However, the results of the developmental profile of Pyk expression by Northern blot analysis suggested that the effects of ecdysone on Pyk were repressive, not inductive [7].
  • Southern blot analysis, PCR, and sequencing were used to determine the content of a Drosophila pyruvate kinase (Pyk) genomic clone, lambdaPK61 [7].


  1. Redox-regulated expression of glycolytic enzymes in resting and proliferating rat thymocytes. Hamm-Künzelmann, B., Schäfer, D., Weigert, C., Brand, K. FEBS Lett. (1997) [Pubmed]
  2. Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules. Lee, B.A., Maher, D.W., Hannink, M., Donoghue, D.J. Mol. Cell. Biol. (1987) [Pubmed]
  3. Sp family members and nuclear factor-Y cooperatively stimulate transcription from the rat pyruvate kinase M gene distal promoter region via their direct interactions. Yamada, K., Tanaka, T., Miyamoto, K., Noguchi, T. J. Biol. Chem. (2000) [Pubmed]
  4. A novel adenosine triphosphate analog with a heavy atom to target the nucleotide binding site of proteins. Naber, N., Matuska, M., Sablin, E.P., Pate, E., Cooke, R. Protein Sci. (1995) [Pubmed]
  5. Role of the stimulatory proteins Sp1 and Sp3 in the regulation of transcription of the rat pyruvate kinase M gene. Netzker, R., Weigert, C., Brand, K. Eur. J. Biochem. (1997) [Pubmed]
  6. Localization of a dosage sensitive region for pyruvate kinase in Drosophila melanogaster. Rust, K.J., Collier, G.E. J. Hered. (1985) [Pubmed]
  7. Cloning and functional analysis of pyruvate kinase promoter region from Drosophila melanogaster. Hsiao, P.F., Zhu, Y.J., Chien, Y.C. DNA Cell Biol. (2002) [Pubmed]
  8. Changes of enzyme activity in larval salivary glands following the induction of respiration dependent puffs in giant chromosomes of Drosophila melanogaster. Behnel, H.J. Cell Differ. (1978) [Pubmed]
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