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Gene Review

CADM1  -  cell adhesion molecule 1

Homo sapiens

Synonyms: BL2, Cell adhesion molecule 1, IGSF4, IGSF4A, IgSF4, ...
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Disease relevance of CADM1


High impact information on CADM1


Chemical compound and disease context of CADM1


Biological context of CADM1


Anatomical context of CADM1


Associations of CADM1 with chemical compounds


Other interactions of CADM1


Analytical, diagnostic and therapeutic context of CADM1


  1. Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis. Murakami, Y. Cancer Sci. (2005) [Pubmed]
  2. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Kuramochi, M., Fukuhara, H., Nobukuni, T., Kanbe, T., Maruyama, T., Ghosh, H.P., Pletcher, M., Isomura, M., Onizuka, M., Kitamura, T., Sekiya, T., Reeves, R.H., Murakami, Y. Nat. Genet. (2001) [Pubmed]
  3. Induction of somatic mutation in a human B cell line in vitro. Denépoux, S., Razanajaona, D., Blanchard, D., Meffre, G., Capra, J.D., Banchereau, J., Lebecque, S. Immunity (1997) [Pubmed]
  4. Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas. Heller, G., Fong, K.M., Girard, L., Seidl, S., End-Pfützenreuter, A., Lang, G., Gazdar, A.F., Minna, J.D., Zielinski, C.C., Zöchbauer-Müller, S. Oncogene (2006) [Pubmed]
  5. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. Yageta, M., Kuramochi, M., Masuda, M., Fukami, T., Fukuhara, H., Maruyama, T., Shibuya, M., Murakami, Y. Cancer Res. (2002) [Pubmed]
  6. Resistance to fludarabine-induced apoptosis in Epstein-Barr virus infected B cells. Fagard, R., Mouas, H., Dusanter-Fourt, I., Devillers, C., Bissières, P., Martin, A., Lenoir, G., VanTan, H., Feuillard, J., Raphaël, M. Oncogene (2002) [Pubmed]
  7. Antiviral agent cidofovir decreases Epstein-Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies. Abdulkarim, B., Sabri, S., Zelenika, D., Deutsch, E., Frascogna, V., Klijanienko, J., Vainchenker, W., Joab, I., Bourhis, J. Oncogene (2003) [Pubmed]
  8. Reduced expression of the Tslc1 gene and its aberrant DNA methylation in rat lung tumors. Shimizu, K., Itsuzaki, Y., Onishi, M., Fujii, H., Honoki, K., Tsujiuchi, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function. Watabe, K., Ito, A., Koma, Y.I., Kitamura, Y. Histol. Histopathol. (2003) [Pubmed]
  10. Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. van der Weyden, L., Arends, M.J., Chausiaux, O.E., Ellis, P.J., Lange, U.C., Surani, M.A., Affara, N., Murakami, Y., Adams, D.J., Bradley, A. Mol. Cell. Biol. (2006) [Pubmed]
  11. IGSF4 promoter methylation and expression silencing in human cervical cancer. Li, J., Zhang, Z., Bidder, M., Funk, M.C., Nguyen, L., Goodfellow, P.J., Rader, J.S. Gynecol. Oncol. (2005) [Pubmed]
  12. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Sasaki, H., Nishikata, I., Shiraga, T., Akamatsu, E., Fukami, T., Hidaka, T., Kubuki, Y., Okayama, A., Hamada, K., Okabe, H., Murakami, Y., Tsubouchi, H., Morishita, K. Blood (2005) [Pubmed]
  13. The tumor suppressor protein TSLC1 is involved in cell-cell adhesion. Masuda, M., Yageta, M., Fukuhara, H., Kuramochi, M., Maruyama, T., Nomoto, A., Murakami, Y. J. Biol. Chem. (2002) [Pubmed]
  14. Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. Fukami, T., Fukuhara, H., Kuramochi, M., Maruyama, T., Isogai, K., Sakamoto, M., Takamoto, S., Murakami, Y. Int. J. Cancer (2003) [Pubmed]
  15. Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs. Jansen, M., Fukushima, N., Rosty, C., Walter, K., Altink, R., Heek, T.V., Hruban, R., Offerhaus, J.G., Goggins, M. Cancer Biol. Ther. (2002) [Pubmed]
  16. Regulation of Fc receptor for IgE (CD23) and class II MHC antigen expression on Burkitt's lymphoma cell lines by human IL-4 and IFN-gamma. Rousset, F., Malefijt, R.W., Slierendregt, B., Aubry, J.P., Bonnefoy, J.Y., Defrance, T., Banchereau, J., de Vries, J.E. J. Immunol. (1988) [Pubmed]
  17. The block of elongation in c-myc exon 1 is abolished in Burkitt's lymphoma cell lines with variant translocation. Eick, D., Polack, A., Kofler, E., Bornkamm, G.W. Oncogene (1988) [Pubmed]
  18. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. Fukuhara, H., Masuda, M., Yageta, M., Fukami, T., Kuramochi, M., Maruyama, T., Kitamura, T., Murakami, Y., Masvuda, M. Oncogene (2003) [Pubmed]
  19. DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. Zhang, J., Martins, C.R., Fansler, Z.B., Roemer, K.L., Kincaid, E.A., Gustafson, K.S., Heitjan, D.F., Clark, D.P. Clin. Cancer Res. (2005) [Pubmed]
  20. Epigenetic inactivation of TSLC1 gene in nasopharyngeal carcinoma. Hui, A.B., Lo, K.W., Kwong, J., Lam, E.C., Chan, S.Y., Chow, L.S., Chan, A.S., Teo, P.M., Huang, D.P. Mol. Carcinog. (2003) [Pubmed]
  21. Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. Mao, X., Seidlitz, E., Truant, R., Hitt, M., Ghosh, H.P. Oncogene (2004) [Pubmed]
  22. Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival. Surace, E.I., Lusis, E., Murakami, Y., Scheithauer, B.W., Perry, A., Gutmann, D.H. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  23. Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung. Uchino, K., Ito, A., Wakayama, T., Koma, Y., Okada, T., Ohbayashi, C., Iseki, S., Kitamura, Y., Tsubota, N., Okita, Y., Okada, M. Cancer (2003) [Pubmed]
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