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Mlc2  -  Myosin light chain 2

Drosophila melanogaster

Synonyms: CG2184, DmMLC2, Dmel\CG2184, Dmlc, Dmlc2, ...
 
 
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High impact information on Mlc2

 

Biological context of Mlc2

 

Anatomical context of Mlc2

  • Two distinct factor-binding DNA elements in cardiac myosin light chain 2 gene are essential for repression of its expression in skeletal muscle. Isolation of a cDNA clone for repressor protein Nished [6].
 

Associations of Mlc2 with chemical compounds

  • The protein sequence derived from translation of the cDNA sequence shows a high degree of homology with that for the DTNB myosin light chain (MLC-2) of chicken [7].
 

Enzymatic interactions of Mlc2

  • The I(20)/I(10) equatorial intensity ratio of the mutant fly is 35% less than that of wild type, supporting the hypothesis that myosin heads that lack phosphorylated RLC remain close to the thick filament backbone [4].
 

Other interactions of Mlc2

 

Analytical, diagnostic and therapeutic context of Mlc2

References

  1. Type II myosin regulatory light chain relieves auto-inhibition of myosin-heavy-chain function. Naqvi, N.I., Wong, K.C., Tang, X., Balasubramanian, M.K. Nat. Cell Biol. (2000) [Pubmed]
  2. Myosin light chain-2 mutation affects flight, wing beat frequency, and indirect flight muscle contraction kinetics in Drosophila. Warmke, J., Yamakawa, M., Molloy, J., Falkenthal, S., Maughan, D. J. Cell Biol. (1992) [Pubmed]
  3. Isolation and characterization of the gene for myosin light chain two of Drosophila melanogaster. Toffenetti, J., Mischke, D., Pardue, M.L. J. Cell Biol. (1987) [Pubmed]
  4. In vivo x-ray diffraction of indirect flight muscle from Drosophila melanogaster. Irving, T.C., Maughan, D.W. Biophys. J. (2000) [Pubmed]
  5. The effect of removing the N-terminal extension of the Drosophila myosin regulatory light chain upon flight ability and the contractile dynamics of indirect flight muscle. Moore, J.R., Dickinson, M.H., Vigoreaux, J.O., Maughan, D.W. Biophys. J. (2000) [Pubmed]
  6. Two distinct factor-binding DNA elements in cardiac myosin light chain 2 gene are essential for repression of its expression in skeletal muscle. Isolation of a cDNA clone for repressor protein Nished. Dhar, M., Mascareno, E.M., Siddiqui, M.A. J. Biol. Chem. (1997) [Pubmed]
  7. Characterization of the myosin light-chain-2 gene of Drosophila melanogaster. Parker, V.P., Falkenthal, S., Davidson, N. Mol. Cell. Biol. (1985) [Pubmed]
  8. Co-localization to chromosome bands 99E1-3 of the Drosophila melanogaster myosin light chain-2 gene and a haplo-insufficient locus that affects flight behavior. Warmke, J.W., Kreuz, A.J., Falkenthal, S. Genetics (1989) [Pubmed]
  9. Phosphorylation-dependent power output of transgenic flies: an integrated study. Dickinson, M.H., Hyatt, C.J., Lehmann, F.O., Moore, J.R., Reedy, M.C., Simcox, A., Tohtong, R., Vigoreaux, J.O., Yamashita, H., Maughan, D.W. Biophys. J. (1997) [Pubmed]
 
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