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Gene Review

KLK12  -  kallikrein-related peptidase 12

Homo sapiens

Synonyms: KLK-L5, KLKL5, Kallikrein-12, Kallikrein-like protein 5, UNQ669/PRO1303
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Disease relevance of KLK12


High impact information on KLK12


Biological context of KLK12

  • Here, we report the production of recombinant KLK12 and analyses of its enzymatic characteristics, including zymogen activation, substrate specificity, and regulation of its activity [1].

Associations of KLK12 with chemical compounds

  • It has been predicted that KLK12 is a secreted serine protease [1].
  • Through screening of a panel of fluorogenic and chromogenic peptide substrates, we establish that active KLK12 possesses trypsin-like activity, cleaving peptide bonds after both arginine and lysine [1].

Regulatory relationships of KLK12


  1. Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). Memari, N., Jiang, W., Diamandis, E.P., Luo, L.Y. Biol. Chem. (2007) [Pubmed]
  2. KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. Yousef, G.M., Magklara, A., Diamandis, E.P. Genomics (2000) [Pubmed]
  3. Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. Shinmura, K., Tao, H., Yamada, H., Kataoka, H., Sanjar, R., Wang, J., Yoshimura, K., Sugimura, H. Hum. Mutat. (2004) [Pubmed]
  4. The antiangiogenic tissue kallikrein pattern of endothelial cells in systemic sclerosis. Giusti, B., Serratì, S., Margheri, F., Papucci, L., Rossi, L., Poggi, F., Magi, A., Del Rosso, A., Cinelli, M., Guiducci, S., Kahaleh, B., Matucci-Cerinic, M., Abbate, R., Fibbi, G., Del Rosso, M. Arthritis Rheum. (2005) [Pubmed]
  5. Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages. Komatsu, N., Takata, M., Otsuki, N., Toyama, T., Ohka, R., Takehara, K., Saijoh, K. J. Invest. Dermatol. (2003) [Pubmed]
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