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Gene Review

IFT74  -  intraflagellar transport 74

Homo sapiens

Synonyms: CCDC2, CMG-1, CMG1, Capillary morphogenesis gene 1 protein, Coiled-coil domain-containing protein 2, ...
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Disease relevance of IFT74


High impact information on IFT74


Chemical compound and disease context of IFT74

  • Selection of Anthrax Toxin Protective Antigen Variants That Discriminate between the Cellular Receptors TEM8 and CMG2 and Achieve Targeting of Tumor Cells [2].
  • We hypothesized that exposure of mice to severe hypoxia would promote the expression of genes involved in capillary morphogenesis and glucose over fatty acid metabolism in active or disused soleus muscle of mice [7].

Biological context of IFT74


Anatomical context of IFT74


Associations of IFT74 with chemical compounds


Regulatory relationships of IFT74


Other interactions of IFT74


Analytical, diagnostic and therapeutic context of IFT74


  1. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Hanks, S., Adams, S., Douglas, J., Arbour, L., Atherton, D.J., Balci, S., Bode, H., Campbell, M.E., Feingold, M., Keser, G., Kleijer, W., Mancini, G., McGrath, J.A., Muntoni, F., Nanda, A., Teare, M.D., Warman, M., Pope, F.M., Superti-Furga, A., Futreal, P.A., Rahman, N. Am. J. Hum. Genet. (2003) [Pubmed]
  2. Selection of Anthrax Toxin Protective Antigen Variants That Discriminate between the Cellular Receptors TEM8 and CMG2 and Achieve Targeting of Tumor Cells. Chen, K.H., Liu, S., Bankston, L.A., Liddington, R.C., Leppla, S.H. J. Biol. Chem. (2007) [Pubmed]
  3. How does extracellular matrix control capillary morphogenesis? Ingber, D.E., Folkman, J. Cell (1989) [Pubmed]
  4. A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis. Nguyen, M., Strubel, N.A., Bischoff, J. Nature (1993) [Pubmed]
  5. Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in the human endometrium. Iruela-Arispe, M.L., Porter, P., Bornstein, P., Sage, E.H. J. Clin. Invest. (1996) [Pubmed]
  6. Primary cilia of human endothelial cells disassemble under laminar shear stress. Iomini, C., Tejada, K., Mo, W., Vaananen, H., Piperno, G. J. Cell Biol. (2004) [Pubmed]
  7. Hypoxia-induced gene activity in disused oxidative muscle. D??pp, C., Gassmann, M., Hoppeler, H., Fl??ck, M. Adv. Exp. Med. Biol. (2006) [Pubmed]
  8. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. Bell, S.E., Mavila, A., Salazar, R., Bayless, K.J., Kanagala, S., Maxwell, S.A., Davis, G.E. J. Cell. Sci. (2001) [Pubmed]
  9. Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. Momeni, P., Schymick, J., Jain, S., Cookson, M.R., Cairns, N.J., Greggio, E., Greenway, M.J., Berger, S., Pickering-Brown, S., Chi??, A., Fung, H.C., Holtzman, D.M., Huey, E.D., Wassermann, E.M., Adamson, J., Hutton, M.L., Rogaeva, E., St George-Hyslop, P., Rothstein, J.D., Hardiman, O., Grafman, J., Singleton, A., Hardy, J., Traynor, B.J. BMC neurology (2006) [Pubmed]
  10. Periodontal treatment of two siblings with juvenile hyaline fibromatosis. Hakki, S.S., Ataoglu, T., Avunduk, M.C., Erdemli, E., Gunhan, O., Rahman, N. Journal of clinical periodontology. (2005) [Pubmed]
  11. Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. Wigelsworth, D.J., Krantz, B.A., Christensen, K.A., Lacy, D.B., Juris, S.J., Collier, R.J. J. Biol. Chem. (2004) [Pubmed]
  12. Quantitative measurement of anthrax toxin receptor messenger RNA in primary mononuclear phagocytes. Premanandan, C., Lairmore, M.D., Fernandez, S., Phipps, A.J. Microb. Pathog. (2006) [Pubmed]
  13. Fibroblast growth factor-2-mediated capillary morphogenesis of endothelial cells requires signals via Flt-1/vascular endothelial growth factor receptor-1: possible involvement of c-Akt. Kanda, S., Miyata, Y., Kanetake, H. J. Biol. Chem. (2004) [Pubmed]
  14. Capillary morphogenesis gene-2 mutation in infantile systemic hyalinosis: ultrastructural study and mutation analysis in a Taiwanese infant. Lee, J.Y., Tsai, Y.M., Chao, S.C., Tu, Y.F. Clin. Exp. Dermatol. (2005) [Pubmed]
  15. Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. Kanda, S., Mochizuki, Y., Suematsu, T., Miyata, Y., Nomata, K., Kanetake, H. J. Biol. Chem. (2003) [Pubmed]
  16. Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Aimes, R.T., Zijlstra, A., Hooper, J.D., Ogbourne, S.M., Sit, M.L., Fuchs, S., Gotley, D.C., Quigley, J.P., Antalis, T.M. Thromb. Haemost. (2003) [Pubmed]
  17. The role of c-Fes in vascular endothelial growth factor-A-mediated signaling by endothelial cells. Kanda, S., Mochizuki, Y., Miyata, Y., Kanetake, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  18. The antiangiogenic tissue kallikrein pattern of endothelial cells in systemic sclerosis. Giusti, B., Serratì, S., Margheri, F., Papucci, L., Rossi, L., Poggi, F., Magi, A., Del Rosso, A., Cinelli, M., Guiducci, S., Kahaleh, B., Matucci-Cerinic, M., Abbate, R., Fibbi, G., Del Rosso, M. Arthritis Rheum. (2005) [Pubmed]
  19. Fibronectin fragments modulate human retinal capillary cell proliferation and migration. Grant, M.B., Caballero, S., Bush, D.M., Spoerri, P.E. Diabetes (1998) [Pubmed]
  20. Homeobox B3 promotes capillary morphogenesis and angiogenesis. Myers, C., Charboneau, A., Boudreau, N. J. Cell Biol. (2000) [Pubmed]
  21. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Scobie, H.M., Rainey, G.J., Bradley, K.A., Young, J.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  22. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Lacy, D.B., Wigelsworth, D.J., Scobie, H.M., Young, J.A., Collier, R.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  23. Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Burns, J.S., Abdallah, B.M., Guldberg, P., Rygaard, J., Schrøder, H.D., Kassem, M. Cancer Res. (2005) [Pubmed]
  24. Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow. Semino, C.E., Kamm, R.D., Lauffenburger, D.A. Exp. Cell Res. (2006) [Pubmed]
  25. Regulators of G-protein signalling: multifunctional proteins with impact on signalling in the cardiovascular system. Wieland, T., Mittmann, C. Pharmacol. Ther. (2003) [Pubmed]
  26. Systemic sclerosis fibroblasts inhibit in vitro angiogenesis by MMP-12-dependent cleavage of the endothelial cell urokinase receptor. Serratì, S., Cinelli, M., Margheri, F., Guiducci, S., Del Rosso, A., Pucci, M., Fibbi, G., Bazzichi, L., Bombardieri, S., Matucci-Cerinic, M., Del Rosso, M. J. Pathol. (2006) [Pubmed]
  27. Role of hypoxia in growth factor responses: differential effects of basic fibroblast growth factor and platelet-derived growth factor in an ischemic wound model. Mustoe, T.A., Tae Ahn, S., Tarpley, J.E., Pierce, G.F. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (1994) [Pubmed]
  28. Differential gene expression during capillary morphogenesis in a microcarrier-based three-dimensional in vitro model of angiogenesis with focus on chemokines and chemokine receptors. Sun, X.T., Zhang, M.Y., Shu, C., Li, Q., Yan, X.G., Cheng, N., Qiu, Y.D., Ding, Y.T. World J. Gastroenterol. (2005) [Pubmed]
  29. Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer. Chu, J., Lloyd, F.L., Trifan, O.C., Knapp, B., Rizzo, M.T. Mol. Cancer Ther. (2003) [Pubmed]
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