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Gene Review

KLK11  -  kallikrein-related peptidase 11

Homo sapiens

Synonyms: Hippostasin, Kallikrein-11, PRSS20, Serine protease 20, TLSP, ...
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Disease relevance of KLK11


High impact information on KLK11


Chemical compound and disease context of KLK11


Biological context of KLK11


Anatomical context of KLK11


Associations of KLK11 with chemical compounds

  • Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family [13].
  • TLSP expression appears to be regulated by steroid hormones in the breast carcinoma cell line BT-474 [13].
  • 8. Functional characterization of beta-HMT suggests that it is not a trypsin-like protease, since neither alpha,N-tosyl-L-lysylchloromethylketone nor alpha,N-tosyl-L-arginyl methyl ester are capable of causing significant inhibition of the cell-lytic activity of the molecule [16].
  • When baby hamster kidney (BHK) cells were grown in medium containing leupeptin, a potent serine-cysteine protease inhibitor, the trypsin-like protease activity (PABI) in the cells increased its level more than 100-fold over the control [17].
  • Extraction of the adenylate cyclase-activating factor of bovine sperm and its identification as a trypsin-like protease [18].

Physical interactions of KLK11


Enzymatic interactions of KLK11


Regulatory relationships of KLK11


Other interactions of KLK11

  • Several other kallikreins, including kallikreins 2 (KLK2) and 11 (KLK11) are emerging as complementary prostate cancer biomarkers [24].
  • Serum total PSA concentration was found to be lower in patients with overexpression of KLK11 (p = 0.044) [12].
  • PURPOSE: The purpose of this study was to examine expression levels of the human tissue kallikrein 11 gene (KLK11) in epithelial ovarian tumors and to identify the relationship between KLK11 expression and patient survival [2].
  • The enzyme activity was similar to that of brain-type hippostasin, which has kallikrein-like activity [25].
  • Two types of KLK11 isoforms, isoform 1 and isoform 2, have been predicted from cDNA sequences [26].

Analytical, diagnostic and therapeutic context of KLK11


  1. Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines. Nakamura, T., Mitsui, S., Okui, A., Kominami, K., Nomoto, T., Ukimura, O., Kawauchi, A., Miki, T., Yamaguchi, N. Prostate (2001) [Pubmed]
  2. Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer. Shigemasa, K., Gu, L., Tanimoto, H., O'Brien, T.J., Ohama, K. Clin. Cancer Res. (2004) [Pubmed]
  3. Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues. Planque, C., Aïnciburu, M., Heuzé-Vourc'h, N., Régina, S., de Monte, M., Courty, Y. Biol. Chem. (2006) [Pubmed]
  4. Ultrastructural demonstration of trypsin-like protease in acrosomes of sea urchin sperm. Green, J.D., Summers, R.G. Science (1980) [Pubmed]
  5. Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32. Adjei, P.N., Kaufmann, S.H., Leung, W.Y., Mao, F., Gores, G.J. J. Clin. Invest. (1996) [Pubmed]
  6. Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains. Kitamoto, Y., Yuan, X., Wu, Q., McCourt, D.W., Sadler, J.E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Nucleotide-stimulated proteolysis of histone H1. Surowy, C.S., Berger, N.A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  8. Global gene expression profiling of pleural mesotheliomas: overexpression of aurora kinases and P16/CDKN2A deletion as prognostic factors and critical evaluation of microarray-based prognostic prediction. López-Ríos, F., Chuai, S., Flores, R., Shimizu, S., Ohno, T., Wakahara, K., Illei, P.B., Hussain, S., Krug, L., Zakowski, M.F., Rusch, V., Olshen, A.B., Ladanyi, M. Cancer Res. (2006) [Pubmed]
  9. Synthesis of N alpha-[3H]acetyl-L-lysine chloromethyl ketone and its use in the fluorographic detection of proteases. Nishikata, M. Anal. Biochem. (1993) [Pubmed]
  10. Human mucus protease inhibitor in airway fluids is a potential defensive compound against infection with influenza A and Sendai viruses. Beppu, Y., Imamura, Y., Tashiro, M., Towatari, T., Ariga, H., Kido, H. J. Biochem. (1997) [Pubmed]
  11. Isolation of a protease from the cell-free medium of in vitro cultured mammary carcinoma. Hakim, A.A. Experientia (1976) [Pubmed]
  12. Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer. Stavropoulou, P., Gregorakis, A.K., Plebani, M., Scorilas, A. Clin. Chim. Acta (2005) [Pubmed]
  13. Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. Yousef, G.M., Scorilas, A., Diamandis, E.P. Genomics (2000) [Pubmed]
  14. Porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 gene expression. Fernando, S.C., Buck, J.S., Ashworth, M.D., Ross, J.W., Geisert, R.D., Desilva, U. Reproduction (2006) [Pubmed]
  15. A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate. Mitsui, S., Yamada, T., Okui, A., Kominami, K., Uemura, H., Yamaguchi, N. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  16. Effector mechanisms of human monocyte-mediated tumor cytotoxicity in vitro: biochemical, functional, and serological characterization of cytotoxins produced by peripheral blood monocytes isolated by counterflow elutriation. Klostergaard, J., Foster, W.A., Hamilton, D.A., Turpin, J., Lopez-Berestein, G. Cancer Res. (1986) [Pubmed]
  17. Isolation and characterization of a novel large protease accumulated in mammalian cells in the presence of inhibitors. Tsuji, A., Kurachi, K. J. Biol. Chem. (1989) [Pubmed]
  18. Extraction of the adenylate cyclase-activating factor of bovine sperm and its identification as a trypsin-like protease. Johnson, R.A., Jakobs, K.H., Schultz, G. J. Biol. Chem. (1985) [Pubmed]
  19. Degradation of a chromogenic substrate by alpha 2-macroglobulin from plasma of patients with rheumatoid arthritis. Teodorescu, M., Gaspar, A., Spear, G., Skosey, J.L., Ganea, D. Arthritis Rheum. (1984) [Pubmed]
  20. Identification of a 10 S trypsin-like protease that cross-reacts with anti-proteasome antibody in sea urchin egg jelly. Inaba, K., Morisawa, M. Arch. Biochem. Biophys. (1995) [Pubmed]
  21. Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). Memari, N., Jiang, W., Diamandis, E.P., Luo, L.Y. Biol. Chem. (2007) [Pubmed]
  22. Involvement of proteases in the action of IFN-gamma on WISH cells. Aharon, M., Dvilansky, A., Shpilberg, O., Nathan, I. J. Interferon Cytokine Res. (2002) [Pubmed]
  23. Salivary histatin as an inhibitor of a protease produced by the oral bacterium Bacteroides gingivalis. Nishikata, M., Kanehira, T., Oh, H., Tani, H., Tazaki, M., Kuboki, Y. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  24. Human tissue kallikreins: The cancer biomarker family. Paliouras, M., Borgono, C., Diamandis, E.P. Cancer Lett. (2007) [Pubmed]
  25. Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate. Nakamura, T., Mitsui, S., Okui, A., Miki, T., Yamaguchi, N. Prostate (2003) [Pubmed]
  26. Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin. Mitsui, S., Nakamura, T., Okui, A., Kominami, K., Uemura, H., Yamaguchi, N. FEBS J. (2006) [Pubmed]
  27. mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy. Scorilas, A., Gregorakis, A.K. Biol. Chem. (2006) [Pubmed]
  28. Purification and characterization of a collagen-degrading protease from Porphyromonas gingivalis. Bedi, G.S., Williams, T. J. Biol. Chem. (1994) [Pubmed]
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