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Gene Review

CanA1  -  Calcineurin A1

Drosophila melanogaster

Synonyms: CAN A1/PP2B, CG1455, CNA1, Calmodulin-dependent calcineurin A1 subunit, Can, ...
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Disease relevance of CanA1

  • Inhibition, mutation, or forced expression of calcineurin pathway genes result in defects or alterations in cardiomyocyte maturation, heart valve formation, vascular development, skeletal muscle differentiation and fiber-type switching, and cardiac and skeletal muscle hypertrophy [1].
  • The interstitial deletion D14 affecting the importin-alpha 2 gene of Drosophila, or imp-alpha 2(D14), causes recessive female sterility characterized by a block of nurse cell-oocyte transport during oogenesis [2].

Psychiatry related information on CanA1


High impact information on CanA1

  • The Ca(2+)-dependent protein phosphatase, calcineurin, binds the cyclophilin-cyclosporin A and FKBP-FK506 complexes, indicating that calcineurin might mediate the actions of these drugs [4].
  • Cryptococcus neoformans cbp1 mutant strains exhibit modest defects in growth under stress conditions and virulence, similar to but less severe than the phenotypes of calcineurin mutants [5].
  • Calcineurin is the conserved target of the immunosuppressants cyclosporin A and FK506 [5].
  • In vitro and in vivo, the CsA-resistant calcineurin mutants bind FKBP12-FK506 but have reduced affinity for cyclophilin A-CsA [6].
  • Together, these findings demonstrate a vital role for the phosphatase in this specific facet of Drosophila myogenesis and show conserved fly and vertebrate calcineurin genes contribute prominently to fundamental processes of muscle formation and function [7].

Biological context of CanA1


Anatomical context of CanA1


Associations of CanA1 with chemical compounds


Other interactions of CanA1


Analytical, diagnostic and therapeutic context of CanA1

  • Molecular cloning and characterization of the genes encoding the two subunits of Drosophila melanogaster calcineurin [9].
  • The PCR analyses also point to the presence in Drosophila and mammals of three or more different genes encoding PP2B, the enzyme recently identified as the target of certain immunosuppressant drugs [13].


  1. Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Schulz, R.A., Yutzey, K.E. Dev. Biol. (2004) [Pubmed]
  2. Importin-alpha 2 is critically required for the assembly of ring canals during Drosophila oogenesis. Gorjánácz, M., Adám, G., Török, I., Mechler, B.M., Szlanka, T., Kiss, I. Dev. Biol. (2002) [Pubmed]
  3. Calcineurin in animal behavior. Lee, J.I., Ahnn, J. Mol. Cells (2004) [Pubmed]
  4. High brain densities of the immunophilin FKBP colocalized with calcineurin. Steiner, J.P., Dawson, T.M., Fotuhi, M., Glatt, C.E., Snowman, A.M., Cohen, N., Snyder, S.H. Nature (1992) [Pubmed]
  5. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. Görlach, J., Fox, D.S., Cutler, N.S., Cox, G.M., Perfect, J.R., Heitman, J. EMBO J. (2000) [Pubmed]
  6. Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. Cardenas, M.E., Muir, R.S., Breuder, T., Heitman, J. EMBO J. (1995) [Pubmed]
  7. Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila. Gajewski, K., Wang, J., Molkentin, J.D., Chen, E.H., Olson, E.N., Schulz, R.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. cDNA cloning of calcineurin heterosubunits from the pheromone gland of the silkmoth, Bombyx mori. Yoshiga, T., Yokoyama, N., Imai, N., Ohnishi, A., Moto, K., Matsumoto, S. Insect Biochem. Mol. Biol. (2002) [Pubmed]
  9. Molecular cloning and characterization of the genes encoding the two subunits of Drosophila melanogaster calcineurin. Guerini, D., Montell, C., Klee, C.B. J. Biol. Chem. (1992) [Pubmed]
  10. Ectopic expression of the homeobox gene Cux-1 rescues calcineurin inhibition in mouse embryonic kidney cultures. Alcalay, N.I., Brantley, J.G., Sharma, M., Gooch, J.L., Vanden Heuvel, G.B. Dev. Dyn. (2007) [Pubmed]
  11. Calcineurin function is required for myofilament formation and troponin I isoform transition in Drosophila indirect flight muscle. Gajewski, K.M., Wang, J., Schulz, R.A. Dev. Biol. (2006) [Pubmed]
  12. Molecular and biochemical characterization of a Plasmodium falciparum cyclophilin containing a cleavable signal sequence. Hirtzlin, J., Färber, P.M., Franklin, R.M., Bell, A. Eur. J. Biochem. (1995) [Pubmed]
  13. Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases. Chen, M.X., Chen, Y.H., Cohen, P.T. FEBS Lett. (1992) [Pubmed]
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