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Gene Review

sty  -  sprouty

Drosophila melanogaster

Synonyms: CG1921, CS3-3, Dmel\CG1921, Protein sprouty, STY, ...
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Disease relevance of sty


High impact information on sty

  • The Egfr triggers cell recruitment in the eye, and sprouty- eyes have excess photoreceptors, cone cells, and pigment cells [2].
  • Our results indicate that Sprouty is a widespread inhibitor of Ras pathway signal transduction [2].
  • In contrast to an earlier proposal that Sprouty is extracellular, we show by biochemical analysis that Sprouty is an intracellular protein, associated with the inner surface of the plasma membrane [2].
  • sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways [3].
  • These two proteins contain a cysteine-rich domain related to Sprouty (the SPR domain) at the carboxy terminus [4].

Biological context of sty


Anatomical context of sty


Associations of sty with chemical compounds

  • Thus, Sprouty may regulate angiogenesis in normal and disease processes by modulating signaling by endothelial tyrosine kinases [1].

Physical interactions of sty

  • Substrate-trapping forms of Corkscrew bind Sprouty in cultured Drosophila cells and the developing eye [13].

Regulatory relationships of sty

  • Similarly, in wing imaginal discs, ectopic Sprouty abolishes activated MAP kinase induced by the EGF receptor pathway [7].
  • At the stage when dorso-ventral polarity of the follicle cells is established, Sprouty limits the ventral expansion of the activating Gurken signal [7].
  • The Drosophila Sprouty (SPRY) protein has been shown to inhibit the actions of epidermal growth factor and fibroblast growth factor [15].

Other interactions of sty


  1. Inhibition of angiogenesis by a mouse sprouty protein. Lee, S.H., Schloss, D.J., Jarvis, L., Krasnow, M.A., Swain, J.L. J. Biol. Chem. (2001) [Pubmed]
  2. Sprouty, an intracellular inhibitor of Ras signaling. Casci, T., Vinós, J., Freeman, M. Cell (1999) [Pubmed]
  3. sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y., Krasnow, M.A. Cell (1998) [Pubmed]
  4. Spred is a Sprouty-related suppressor of Ras signalling. Wakioka, T., Sasaki, A., Kato, R., Shouda, T., Matsumoto, A., Miyoshi, K., Tsuneoka, M., Komiya, S., Baron, R., Yoshimura, A. Nature (2001) [Pubmed]
  5. Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Kramer, S., Okabe, M., Hacohen, N., Krasnow, M.A., Hiromi, Y. Development (1999) [Pubmed]
  6. Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling. Wong, E.S., Fong, C.W., Lim, J., Yusoff, P., Low, B.C., Langdon, W.Y., Guy, G.R. EMBO J. (2002) [Pubmed]
  7. Sprouty is a general inhibitor of receptor tyrosine kinase signaling. Reich, A., Sapir, A., Shilo, B. Development (1999) [Pubmed]
  8. Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation. Gross, I., Bassit, B., Benezra, M., Licht, J.D. J. Biol. Chem. (2001) [Pubmed]
  9. Regulation of sprouty stability by Mnk1-dependent phosphorylation. DaSilva, J., Xu, L., Kim, H.J., Miller, W.T., Bar-Sagi, D. Mol. Cell. Biol. (2006) [Pubmed]
  10. Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling. Chambers, D., Mason, I. Mech. Dev. (2000) [Pubmed]
  11. Human SPRY2 inhibits FGF2 signalling by a secreted factor. Glienke, J., Fenten, G., Seemann, M., Sturz, A., Thierauch, K.H. Mech. Dev. (2000) [Pubmed]
  12. Direct control of transcription of the Drosophila morphogen bicoid by the serendipity delta zinc finger protein, as revealed by in vivo analysis of a finger swap. Payre, F., Crozatier, M., Vincent, A. Genes Dev. (1994) [Pubmed]
  13. Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases. Jarvis, L.A., Toering, S.J., Simon, M.A., Krasnow, M.A., Smith-Bolton, R.K. Development (2006) [Pubmed]
  14. SUMO represses transcriptional activity of the Drosophila SoxNeuro and human Sox3 central nervous system-specific transcription factors. Savare, J., Bonneaud, N., Girard, F. Mol. Biol. Cell (2005) [Pubmed]
  15. The C terminus of sprouty is important for modulation of cellular migration and proliferation. Yigzaw, Y., Cartin, L., Pierre, S., Scholich, K., Patel, T.B. J. Biol. Chem. (2001) [Pubmed]
  16. Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea. Ohshiro, T., Emori, Y., Saigo, K. Mech. Dev. (2002) [Pubmed]
  17. Evidence for direct interaction between Sprouty and Cbl. Wong, E.S., Lim, J., Low, B.C., Chen, Q., Guy, G.R. J. Biol. Chem. (2001) [Pubmed]
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