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Gene Review

dlt  -  discs lost

Drosophila melanogaster

Synonyms: CG1977, CG32315, Codanin 1 homolog, DLT, Dlt, ...
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High impact information on dlt

  • Mutations in dlt or double-stranded RNA interference lead to aberrant localization of CRB and NRX IV and cause a concomitant loss of epithelial cell polarity [1].
  • CONCLUSIONS: We propose a model in which the interaction of the Crumbs carboxyl terminus with Discs Lost organises a membrane-associated protein complex in the apical cytocortex of epithelial cells [2].
  • The P-element insertion was in the intron of a novel gene, Vanaso, which contains a putative guanylate binding protein domain, is highly polymorphic, and is expressed in the third antennal segment, the major olfactory organ of Drosophila [3].
  • Drosophila Crumbs also interacts with two other polarity genes, Stardust and Discs Lost [4].
  • In Drosophila, the genomic organization of dlt is unusual. dlt shares its first untranslated exon with alpha-spectrin, and both genes are coexpressed throughout development [5].

Biological context of dlt


Analytical, diagnostic and therapeutic context of dlt


  1. Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Bhat, M.A., Izaddoost, S., Lu, Y., Cho, K.O., Choi, K.W., Bellen, H.J. Cell (1999) [Pubmed]
  2. A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila. Klebes, A., Knust, E. Curr. Biol. (2000) [Pubmed]
  3. Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior. Fanara, J.J., Robinson, K.O., Rollmann, S.M., Anholt, R.R., Mackay, T.F. Genetics (2002) [Pubmed]
  4. Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). Makarova, O., Roh, M.H., Liu, C.J., Laurinec, S., Margolis, B. Gene (2003) [Pubmed]
  5. The Drosophila cell survival gene discs lost encodes a cytoplasmic Codanin-1-like protein, not a homolog of tight junction PDZ protein Patj. Pielage, J., Stork, T., Bunse, I., Klämbt, C. Dev. Cell (2003) [Pubmed]
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