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Gene Review

BDKRB1  -  bradykinin receptor B1

Canis lupus familiaris

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Disease relevance of BDKRB1


High impact information on BDKRB1


Biological context of BDKRB1


Associations of BDKRB1 with chemical compounds

  • The PGI2-release may be mediated by B1 receptor [7].
  • The new potent B2-receptor antagonist, HOE 140 (100 micrograms), significantly blocked the BK-induced chronotropic effect, whereas desArg9-BK, a B1-receptor agonist, was without effect [8].


  1. Mechanisms of kinin B1-receptor-induced hypotension in the anesthetized dog. Lamontagne, D., Nakhostine, N., Couture, R., Nadeau, R. J. Cardiovasc. Pharmacol. (1996) [Pubmed]
  2. Pharmacological characterization of canine bradykinin receptors in prostatic culture and in isolated prostate. Srinivasan, D., Burbach, L.R., Daniels, D.V., Ford, A.P., Bhattacharya, A. Br. J. Pharmacol. (2004) [Pubmed]
  3. Bradykinin-induced contractions of canine saphenous veins: mediation by B2 receptors and involvement of eicosanoids. Marsault, R., Illiano, S., Vanhoutte, P.M. Br. J. Pharmacol. (1997) [Pubmed]
  4. Structure-activity studies on bradykinin and related peptides: agonists. Rhaleb, N.E., Drapeau, G., Dion, S., Jukic, D., Rouissi, N., Regoli, D. Br. J. Pharmacol. (1990) [Pubmed]
  5. Specific receptors for bradykinin-induced cardiac sympathetic chemoreflex in the dog. Staszewska-Woolley, J., Woolley, G., Regoli, D. Eur. J. Pharmacol. (1988) [Pubmed]
  6. Conversion of kinins and their antagonists into B1 receptor activators and blockers in isolated vessels. Regoli, D., Drapeau, G., Rovero, P., Dion, S., Rhaleb, N.E., Barabé, J., D'Orléans-Juste, P., Ward, P. Eur. J. Pharmacol. (1986) [Pubmed]
  7. Different involvement of endothelium-derived relaxing factor and prostacyclin in vasodilator response to bradykinin in isolated dog blood vessels. Okamura, T., Toda, N. Adv. Exp. Med. Biol. (1989) [Pubmed]
  8. In vivo B2-receptor-mediated negative chronotropic effect of bradykinin in canine sinus node. Ribuot, C., Godin, D., Couture, R., Regoli, D., Nadeau, R. Am. J. Physiol. (1993) [Pubmed]
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